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Increased micronucleus frequencies in reticulocytes of children exposed to industrial pollution: oxidative stress and the OGG1 S326C polymorphism.
Mutation Research/Genetic Toxicology and Environmental Mutagenesis ( IF 1.9 ) Pub Date : 2020-03-14 , DOI: 10.1016/j.mrgentox.2020.503170 Regina D Montero-Montoya 1 , Rocío López-Vargas 1 , Alejandra Méndez-Serrano 2 , Isaías Galicia-Alonso 2 , Guadalupe García-Vargas 2 , Luis Serrano-García 1 , Rosa Beltrán-Portugal 1 , Samuel Rosado-Zaidi 3 , Arnulfo Albores-Medina 4 , Luis Oropeza-Hernández 5 , Leticia Hernández-Cadena 6 , Francisco Mercado-Calderón 7 , Esmeralda Alvarado-Toledo 5 , Selene Herrera-Morales 1 , Omar Arellano-Aguilar 8
中文翻译：
暴露于工业污染的儿童网织红细胞中微核频率增加：氧化应激和 OGG1 S326C 多态性。
更新日期：2020-03-14
Mutation Research/Genetic Toxicology and Environmental Mutagenesis ( IF 1.9 ) Pub Date : 2020-03-14 , DOI: 10.1016/j.mrgentox.2020.503170 Regina D Montero-Montoya 1 , Rocío López-Vargas 1 , Alejandra Méndez-Serrano 2 , Isaías Galicia-Alonso 2 , Guadalupe García-Vargas 2 , Luis Serrano-García 1 , Rosa Beltrán-Portugal 1 , Samuel Rosado-Zaidi 3 , Arnulfo Albores-Medina 4 , Luis Oropeza-Hernández 5 , Leticia Hernández-Cadena 6 , Francisco Mercado-Calderón 7 , Esmeralda Alvarado-Toledo 5 , Selene Herrera-Morales 1 , Omar Arellano-Aguilar 8
Affiliation
We examined possible early-effect biomarkers and polymorphisms of susceptibility in primary school children living near the Atoyac River in central México, which receives waste from multiple industries. We observed a significant increase in micronucleated reticulocytes associated with the oxidative stress index (OSI) and the OGG1 GG (S326C) genotype, and a significant decrease of reticulocytes carrying the transferrin receptor, inversely correlated with OSI.
中文翻译：
暴露于工业污染的儿童网织红细胞中微核频率增加：氧化应激和 OGG1 S326C 多态性。
我们研究了居住在墨西哥中部阿托亚克河附近的小学生可能的早期效应生物标志物和易感性多态性，该河从多个行业接收废物。我们观察到与氧化应激指数 (OSI) 和OGG1 GG (S326C) 基因型相关的微核网织红细胞显着增加，携带转铁蛋白受体的网织红细胞显着减少，与 OSI 呈负相关。
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