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Increased micronucleus frequencies in reticulocytes of children exposed to industrial pollution: oxidative stress and the OGG1 S326C polymorphism.
Mutation Research/Genetic Toxicology and Environmental Mutagenesis ( IF 2.506 ) Pub Date : 2020-03-14 , DOI: 10.1016/j.mrgentox.2020.503170
Regina D Montero-Montoya,Rocío López-Vargas,Alejandra Méndez-Serrano,Isaías Galicia-Alonso,Guadalupe García-Vargas,Luis Serrano-García,Rosa Beltrán-Portugal,Samuel Rosado-Zaidi,Arnulfo Albores-Medina,Luis Oropeza-Hernández,Leticia Hernández-Cadena,Francisco Mercado-Calderón,Esmeralda Alvarado-Toledo,Selene Herrera-Morales,Omar Arellano-Aguilar

We examined possible early-effect biomarkers and polymorphisms of susceptibility in primary school children living near the Atoyac River in central México, which receives waste from multiple industries. We observed a significant increase in micronucleated reticulocytes associated with the oxidative stress index (OSI) and the OGG1 GG (S326C) genotype, and a significant decrease of reticulocytes carrying the transferrin receptor, inversely correlated with OSI.
更新日期:2020-03-14

 

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