Study Objective

This study aimed to evaluate the reproductive potential of patients with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) who were candidates for uterus transplantation (UTx) before inclusion in the experimental trial, and to summarize the existing experience with posttransplantation embryo transfers in functionally successful cases.

Design and Setting

A prospective study at a tertiary medical center.

Participants

Ten pre-UTx women with MRKHS and 7 successful UTx cases.

Interventions and Main Outcome Measures

Ovarian stimulations, frozen embryo collection, embryo transfers, and incidence of pregnancy in MRKHS women in the pre- and posttransplantation periods.

Results

The average number of ovarian stimulations to collect the required frozen embryos was 1.9 (1-3). On average, the number of aspirated oocytes was 16.4 (7-38), 12.6 (5-26) oocytes were fertilized, and 7.0 (1-18) embryos were cryopreserved per cycle. To date, the average number of embryo transfers per recipient was 4.9 (3-8), and the embryo transfer/pregnancy rate was 8.8% (3 of 34). Three pregnancies have been achieved to date, including a missed abortion in the 8th week, a birth in the 35th week, and an ongoing pregnancy in the 30th week.

Conclusions

Despite the small number of UTx cases, our data indicated that women with MRKHS showed a good response to ovarian stimulation and blastocyst formation. Although the procedures for fertilization, cryopreservation, and transfer of the embryos were standardized, the success rate per embryo transfer achieved in the study group has been low to date.

中文翻译：

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Mayer-Rokitansky-Küster-Hauser综合征接受子宫移植的妇女的辅助生殖技术和妊娠结果：捷克经验。

研究目标

这项研究旨在评估Mayer-Rokitansky-Küster-Hauser综合征（MRKHS）的患者的生殖潜能，这些患者在纳入实验试验之前是子宫移植（UTx）的候选人，并总结了功能性移植后胚胎移植的现有经验成功的案例。

设计与设定

三级医疗中心的前瞻性研究。

参加者

十名患有MRKHS的UTx前妇女和7例成功的UTx病例。

干预措施和主要结果

MRKHS妇女在移植前和移植后的卵巢刺激，冷冻胚胎收集，胚胎移植和妊娠率。

结果

卵巢刺激收集所需冷冻胚胎的平均次数为1.9（1-3）。平均而言，每个周期抽吸的卵母细胞数为16.4（7-38），使12.6（5-26）个卵母细胞受精，并冷冻保存7.0（1-18）个胚胎。迄今为止，每个接受者的平均胚胎移植数为4.9（3-8），胚胎移植/妊娠率为8.8％（34个中的3个）。迄今为止，已经完成了三次怀孕，包括在第8周流产，在第35周分娩和在第30周持续怀孕。

结论

尽管UTx病例很少，但我们的数据表明，患有MRKHS的女性对卵巢刺激和囊胚形成表现出良好的反应。尽管标准化了受精，冷冻保存和胚胎移植的程序，但迄今为止，研究组每次胚胎移植的成功率仍然很低。