Host single nucleotide polymorphisms (SNPs) in different genes can play a role in chronic hepatitis C virus (HCV) infection and influence the presence of hepatic fibrosis and comorbidities such as hepatic steatosis. We assessed the combined effect of SNPs in the PNPLA3, MTTP, TM6SF2, and IFNL3/IFNL4 genes in 288 Brazilian patients who were chronically infected with HCV. Hepatic fibrosis was observed in 246 (85.4%) patients and hepatic steatosis in 141 (49.0%) patients. PNPLA3 rs738409 (CG/GG) (P = 0.044) and TM6SF2 rs58542926 (CT) (P = 0.004) were alone associated with fibrosis, and PNPLA3 rs738409 (P < 0.05, in distinct genetic models) was associated with steatosis. Multiple logistic regression of each SNP combined with HCV genotype 3 infection showed that MTTP rs1800591 (GT/TT) combined with HCV genotype 3 was associated with a 6.72-fold increased chance of hepatic steatosis (P = 0.013). In the analysis of SNPs combined 2 by 2, no influence on hepatic fibrosis or steatosis was observed.

中文翻译：

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慢性丙型肝炎病毒基因感染对肝纤维化和脂肪变性的影响。

不同基因中的宿主单核苷酸多态性（SNP）可以在慢性丙型肝炎病毒（HCV）感染中起作用，并影响肝纤维化和合并症（例如肝脂肪变性）的存在。我们评估了288名长期感染HCV的巴西患者中PNPLA3，MTTP，TM6SF2和IFNL3 / IFNL4基因中SNP的综合作用。在246（85.4％）位患者中观察到肝纤维化，在141（49.0％）位患者中观察到肝脂肪变性。PNPLA3 rs738409（CG / GG）（P = 0.044）和TM6SF2 rs58542926（CT）（P = 0.004）单独与纤维化相关，而PNPLA3 rs738409（P <0.05，在不同的遗传模型中）与脂肪变性相关。每个SNP与HCV基因型3感染的多重logistic回归分析显示，MTTP rs1800591（GT / TT）与HCV基因型3感染的相关性为6。肝脂肪变性的机会增加了72倍（P = 0.013）。在SNPs 2比2结合分析中，未观察到对肝纤维化或脂肪变性的影响。