当前位置: X-MOL 学术Biocybern. Biomed. Eng. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A 3D-CNT micro-electrode array for zebrafish ECG study including directionality measurement and drug test
Biocybernetics and Biomedical Engineering ( IF 6.4 ) Pub Date : 2020-03-28 , DOI: 10.1016/j.bbe.2020.02.008
Mulaine Shih , Chia-Tung Kuo , Min-Hsuan Lin , Yung-Jen Chuang , Hsin Chen , Tri-Rung Yew

This study aims to demonstrate the applicability of three dimensional-carbon-nanotubes (3D-CNT) micro-electrode array for electrocardiogram (ECG) study on the premier vertebrate model zebrafish. The small-feature size and vectorial array of 3D-CNT micro-electrodes were designed to detect ECG signals with high spatial resolution. With 30 μm–85 μm spacing between electrodes, it enables to detect the directionality of the ECG signals, the change of the characteristic ECG wave-forms at different locations of an adult zebrafish heart. Besides, the preliminary drug response tests using 3D-CNT micro-electrode were also carried out, which validated the capability of real-time observation on drug-induced ECG signal changes. The 3D-CNT micro-electrode array is thus feasible for ECG research and cardiac drug screenings, and holds high potential for studying bioelectric signals of other living organisms in the future.



中文翻译:

用于斑马鱼心电图研究的3D-CNT微电极阵列,包括方向性测量和药物测试

这项研究旨在证明三维碳纳米管(3D-CNT)微电极阵列在主要脊椎动物模型斑马鱼的心电图(ECG)研究中的适用性。3D-CNT微电极的小尺寸和矢量阵列设计用于检测具有高空间分辨率的ECG信号。电极之间的间距为30 μm–85μm,它可以检测ECG信号的方向性,即成年斑马鱼心脏不同位置的特征性ECG波形的变化。此外,还进行了使用3D-CNT微电极的初步药物反应测试,从而验证了实时观察药物诱发的ECG信号变化的能力。因此,3D-CNT微电极阵列可用于ECG研究和心脏药物筛查,

更新日期:2020-03-28
down
wechat
bug