The potential benefits of supplemental nutrients and dietary interventions against cardiovascular morbidity and mortality have been extensively investigated throughout the years. Numerous supplements claim cardioprotection and reduction of cardiovascular risk factors, but the roles of many supplements have not been determined. In the vast number of supplements on the market asserting cardioprotective effects, only 3 have been thoroughly evaluated and consistently reported as effective by our clinic patients. They have used supplements such as fish oil, multivitamins, and calcium, but many had not known of the benefits of resveratrol, curcumin, and nitric oxide as supplements for improving cardiovascular health. The cardioprotective effects of these dietary supplements in both animal models and humans have been explored with proposed mechanisms of action mostly attributed to antioxidant and anti-inflammatory properties. Resveratrol is one of the most studied polyphenols with established cardiovascular benefits. Preclinical studies have demonstrated these effects exerted via improved inflammatory markers, atherogenic profile, glucose metabolism, and endothelial function and are further supported by clinical trials. Curcumin has a well-established anti-inflammatory role by regulating numerous transcription factors and cytokines linked to inflammation. Inflammation is an underlying pathology in cardiovascular diseases, rendering curcumin a potential therapeutic compound. Similarly, nitric oxide supplementation has demonstrated cardiovascular benefits by normalizing blood pressure; enhancing blood flow; and reducing inflammation, immune dysfunction, and oxidative stress. A comprehensive review was performed evaluating the cardioprotective effects of these 3 dietary supplements with hope to provide updated information, promote further awareness of these supplements, and inspire future studies on their effects on cardiovascular health.

中文翻译：

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白藜芦醇、姜黄素和膳食补充一氧化氮对人类心血管健康的抗氧化和抗炎作用的系统评价

多年来，人们对补充营养素和饮食干预对心血管发病率和死亡率的潜在益处进行了广泛研究。许多补充剂声称可以保护心脏并减少心血管危险因素，但许多补充剂的作用尚未确定。在市场上大量声称具有心脏保护作用的补充剂中，只有 3 种已经被我们的临床患者彻底评估并一致报告为有效。他们使用了鱼油、多种维生素和钙等补充剂，但许多人不知道白藜芦醇、姜黄素和一氧化氮作为改善心血管健康的补充剂的益处。这些膳食补充剂在动物模型和人类中的心脏保护作用已被探索，其作用机制主要归因于抗氧化和抗炎特性。白藜芦醇是研究最多的多酚之一，具有公认的心血管益处。临床前研究已经证明这些影响是通过改善炎症标志物、致动脉粥样硬化特征、葡萄糖代谢和内皮功能发挥的，并得到临床试验的进一步支持。姜黄素通过调节与炎症相关的众多转录因子和细胞因子，具有公认的抗炎作用。炎症是心血管疾病的潜在病理，使姜黄素成为一种潜在的治疗化合物。相似地，一氧化氮补充剂通过使血压正常化显示出心血管益处；促进血液流动；并减少炎症、免疫功能障碍和氧化应激。对这 3 种膳食补充剂的心脏保护作用进行了全面审查，希望提供最新信息，促进对这些补充剂的进一步认识，并激发未来关于它们对心血管健康影响的研究。