Small RNAs (sRNAs) that act by base-pairing have been shown to play important roles in fine-tuning the levels and translation of their target transcripts across a variety of model and pathogenic organisms. Work from many different groups in a wide range of bacterial species has provided evidence for the importance and complexity of sRNA regulatory networks, which allow bacteria to quickly respond to changes in their environment. However, despite the expansive literature, much remains to be learned about all aspects of sRNA-mediated regulation, particularly in bacteria beyond the well-characterized Escherichia coli and Salmonella enterica species. Here we discuss what is known, and what remains to be learned, about the identification of regulatory base-pairing RNAs produced from diverse genomic loci including how their expression is regulated. This article is part of a Special Issue entitled: RNA and gene control in bacteria edited by Dr. M. Guillier and F. Repoila.

中文翻译：

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来自不同基因组基因座的小碱基配对RNA的流行。

已经显示了通过碱基配对起作用的小RNA（sRNA）在微调各种模型和病原生物的目标转录物的水平和翻译中起着重要作用。sRNA调控网络的重要性和复杂性提供了证据，证明了sRNA调控网络的重要性和复杂性，这些因素使细菌能够快速响应其环境变化，从而为细菌的广泛应用提供了证据。但是，尽管文献广泛，但关于sRNA介导调控的各个方面，尤其是在特征明确的大肠杆菌和肠炎沙门氏菌之外的细菌中，仍有许多知识要学习。在这里，我们讨论了有关从各种基因组位点产生的调节性碱基配对RNA的鉴定（包括其表达调控）的已知知识和有待学习的知识。