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Development of a simulation chamber for the evaluation of dermal absorption of volatile organic compounds
Atmospheric Pollution Research ( IF 4.5 ) Pub Date : 2020-02-25 , DOI: 10.1016/j.apr.2020.02.015
Soraya Pontes-López , Julia Moreno , Francesc A. Esteve-Turrillas , Sergio Armenta

An exposition chamber has been designed and developed for the production of contaminated atmospheres with fixed and known concentration of volatile organic compounds. The proposed chamber has been evaluated for the determination of in-vitro diffusion parameters, such as flux and lag time for benzene, toluene, ethylbenzene, and xylenes (BTEX). Polydimethylsiloxane (PDMS) and Strat-M® membranes were evaluated, including the effect of membrane thickness, from 0.5 to 3.0 mm, on the diffusion parameters. The obtained flux values and lag times, ranged from 0.2 to 1.5 μg cm−2 h−1 and from 10 to 130 min, respectively, for studies performed at a BTEX concentration of 51 μg L−1 in air. Different air concentration of BTEX were evaluated in the calibration chamber, indicating that flux increased proportionally to the BTEX concentration in air and the lag time decreased as the air concentration of BTEX increased.



中文翻译:

开发用于评估挥发性有机化合物对皮肤吸收的模拟室

已经设计并开发了一种曝光室,用于产生具有固定浓度和已知浓度的挥发性有机化合物的污染大气。已对拟议的反应室进行了评估,以确定其体外扩散参数,例如苯,甲苯,乙苯和二甲苯(BTEX)的通量和滞后时间。评估了聚二甲基硅氧烷(PDMS)和Strat-M®膜,包括0.5到3.0 mm膜厚度对扩散参数的影响。对于在51μgL -1的BTEX浓度下进行的研究,获得的通量值和滞后时间分别为0.2至1.5μgcm -2 h -1和10至130分钟。在空中。在标定室中评估了不同的BTEX空气浓度,表明通量与空气中BTEX浓度成正比,并且滞后时间随BTEX空气浓度的增加而减少。

更新日期:2020-02-25
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