The last decade has witnessed tremendous progress in immunology and vaccinology, owing to several scientific and technological breakthroughs. Systems vaccinology is a field that has emerged at the forefront of vaccine research and development and provides a unique way to probe immune responses to vaccination in humans. The goals of systems vaccinology are to use systems-based approaches to define signatures that can be used to predict vaccine immunogenicity and efficacy and to delineate the molecular mechanisms driving protective immunity. The application of systems biological approaches in influenza vaccination studies has enabled the discovery of early signatures that predict immunogenicity to vaccination and yielded novel mechanistic insights about vaccine-induced immunity. Here we review the contributions of systems vaccinology to influenza vaccine development and critically examine the potential of systems vaccinology toward enabling the development of a universal influenza vaccine that provides robust and durable immunity against diverse influenza viruses.

中文翻译：

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对流感疫苗接种的免疫反应的系统生物学分析。

由于多项科技突破，过去十年见证了免疫学和疫苗学的巨大进步。系统疫苗学是一个出现在疫苗研发前沿的领域，它提供了一种独特的方法来探测人类对疫苗接种的免疫反应。系统疫苗学的目标是使用基于系统的方法来定义可用于预测疫苗免疫原性和功效的特征，并描述驱动保护性免疫的分子机制。系统生物学方法在流感疫苗接种研究中的应用使得发现预测疫苗免疫原性的早期特征成为可能，并产生了关于疫苗诱导免疫的新机制见解。