Siglec-15 is a member of the Siglec family of glycan-recognition proteins, primarily expressed on a subset of myeloid cells. Siglec-15 has been known to be involved in osteoclast differentiation, and is considered to be a potential therapeutic target for osteoporosis. Recent studies revealed unexpected roles of Siglec-15 in microbial infection and the cancer microenvironment, expanding the potential pathophysiological roles of Siglec-15. Chemical biology has advanced our understanding of the nature of Siglec-15 ligands, but the exact nature of Siglec-15 ligand depends on the biological context, leaving plenty of room for further exploration.

中文翻译：

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Siglec-15：潜在的骨质疏松症，癌症和传染病调节剂

Siglec-15是聚糖识别蛋白Siglec家族的成员，主要在髓样细胞的子集上表达。已知Siglec-15参与破骨细胞分化，并被认为是骨质疏松症的潜在治疗靶标。最近的研究表明，Siglec-15在微生物感染和癌症微环境中具有意想不到的作用，从而扩大了Siglec-15的潜在病理生理作用。化学生物学使我们对Siglec-15配体的性质有了更深入的了解，但是Siglec-15配体的确切性质取决于生物学环境，因此有足够的空间进行进一步的探索。