Vaccination is the most effective measure at preventing influenza virus infections. However, current seasonal influenza vaccines are only protective against closely matched circulating strains. Even with extensive monitoring and annual reformulation our efforts remain one step behind the rapidly evolving virus, often resulting in mismatches and low vaccine effectiveness. Fortunately, many next-generation influenza vaccines are currently in development, utilizing an array of innovative techniques to shorten production time and increase the breadth of protection. This review summarizes the production methods of current vaccines, recent advances that have been made in influenza vaccine research, and highlights potential challenges that are yet to be overcome. Special emphasis is put on the potential role of glycoengineering in influenza vaccine development, and the advantages of removing the glycan shield on influenza surface antigens to increase vaccine immunogenicity. The potential for future development of these novel influenza vaccine candidates is discussed from an industry perspective.

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更好的流感疫苗：行业观点

接种疫苗是预防流感病毒感染的最有效措施。但是，当前的季节性流感疫苗仅能保护紧密匹配的循环株。即使进行了广泛的监控和年度重新制定，我们的努力仍然落后于迅速发展的病毒，这往往会导致错配和疫苗效力低下。幸运的是，目前正在开发许多下一代流感疫苗，它们利用一系列创新技术来缩短生产时间并增加保护范围。这篇综述总结了当前疫苗的生产方法，流感疫苗研究的最新进展，并着重指出了尚待克服的潜在挑战。特别强调了糖工程在流感疫苗开发中的潜在作用，以及去除流感表面抗原上的聚糖屏蔽以增加疫苗免疫原性的优势。从行业的角度讨论了这些新型流感疫苗候选物的未来发展潜力。