当前位置: X-MOL 学术Bioelectrochemistry › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
In vitro attenuation of astrocyte activation and neuroinflammation through ibuprofen-doping of poly(3,4-ethylenedioxypyrrole) formulations.
Bioelectrochemistry ( IF 5 ) Pub Date : 2020-04-08 , DOI: 10.1016/j.bioelechem.2020.107528
Katarzyna Krukiewicz 1 , Agnieszka Kowalik 2 , Roman Turczyn 2 , Manus J P Biggs 3
Affiliation  

Neuroinflammation is often associated with poor functional recovery and may contribute to or initiate the development of severe neurological disorders, such as epilepsy, Parkinson's disease or Alzheimer's disease. Ibuprofen (IBU), being one of the most commonly used non-steroidal anti-inflammatory drugs, is known to possess neuroprotective activity and serve as a promising therapeutic for the treatment of neuroinflammation. In this study, the potential of an IBU-loaded poly(3,4-ethylenedioxypyrrole) (PEDOP) matrix has been assessed as a neural interface material with an aim to control astrocyte activation and suppress neuroinflammation in vitro. Three types of drug immobilization protocols were investigated, leading to the fabrication of IBU-loaded PEDOP matrices exhibiting a broad spectrum of electrical characteristics, drug release profiles, as well as biological responses. Among all investigated PEDOP formulations, PEDOP matrices formed through a three-step immobilization protocol exhibited the highest charge storage capacity (30 ± 1 mC/cm2) as well as a double layer capacitance of 645.0 ± 51.1 µF, associated with a relatively enlarged surface area. Demonstrating a total drug loading capacity of 150 µg/ml and a release rate constant of 0.15 1/h, this coating formulation may be employed as a safe electrical conducting drug eluting system.

中文翻译:

通过布洛芬掺杂的聚(3,4-乙撑二氧基吡咯)制剂体外减轻星形胶质细胞的活化和神经炎症。

神经炎症通常与功能恢复不佳有关,并且可能导致或引发严重的神经系统疾病,例如癫痫,帕金森氏病或阿尔茨海默氏病。布洛芬(IBU)是最常用的非甾体类抗炎药之一,已知具有神经保护活性,可作为治疗神经炎症的有前途的疗法。在这项研究中,已评估了IBU负载的聚(3,4-亚乙二氧基吡咯)(PEDOP)基质作为神经界面材料的潜力,目的是在体外控制星形胶质细胞的活化并抑制神经炎症。研究了三种类型的药物固定方案,从而制得了具有IBU的PEDOP基质,该基质表现出广泛的电特性,药物释放曲线以及生物学反应。在所有研究的PEDOP配方中,通过三步固定方案形成的PEDOP基质具有最高的电荷存储容量(30±1 mC / cm2)以及645.0±51.1 µF的双层电容,并具有相对较大的表面积。该涂料配方的总载药量为150 µg / ml,释放速率常数为0.15 1 / h,可以用作安全的导电药物洗脱系统。
更新日期:2020-04-08
down
wechat
bug