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Bypassing the Immunosuppression of Myeloid‐Derived Suppressor Cells by Reversing Tumor Hypoxia Using a Platelet‐Inspired Platform
Advanced Functional Materials ( IF 19.0 ) Pub Date : 2020-04-06 , DOI: 10.1002/adfm.202000189
Chao Zhang 1 , Donglin Xia 1, 2 , Jiahao Liu 3 , Da Huo 4 , Xiqun Jiang 3 , Yong Hu 1
Affiliation  

Myeloid‐derived suppressor cells (MDSCs) are garnering increasing attention given their role in tumor development. Herein, a nano‐enabled strategy is demonstrated for the eradication of tumor‐infiltrated MDSCs by reversing hypoxia. Oxygen‐independent photodynamic bismuth tungstate nanoparticles (Bi2WO6 NPs) are loaded into reactive oxygen species (ROS) responsive platelet membranes (PMs) to form a hybrid (PM‐BiW NPs). P‐Selectin on PMs endows PM‐BiW NPs with selectivity toward cancer cells. Once in the tumor, laser illumination stimulates the Bi2WO6 NPs photothermally and photodynamically, which produces enormous quantities of hydroxyl radicals. These hydroxyl radicals help rupture the PM and mitigate hypoxia with the assistance of ionizing radiation. This effectively remodels the tumor microenvironment toward one disfavoring the recruitment of MDSCs and contributes to better prognosis. To better understand the mechanism, the expression levels of a set of markers are monitored. It is found that the downregulations of hypoxia‐inducible factor‐1α, ectonucleoside triphosphate diphosphohydrolase 2, and adenosine‐5‐phosphoricacid are behind the blocked infiltration of MDSCs. This platform strategy offers a promising approach to overcome the immunosuppression caused by MDSCs through a trimodal therapy integrating the power of photothermal and photodynamic therapy in addition to radiation therapy.

中文翻译:

通过使用血小板启发的平台逆转肿瘤缺氧来绕过髓样来源的抑制细胞的免疫抑制

由于髓样来源的抑制细胞(MDSC)在肿瘤发展中的作用,因此受到越来越多的关注。本文证明了通过逆转缺氧根除肿瘤浸润的MDSC的纳米策略。不依赖氧的光动力钨酸铋铋纳米颗粒(Bi 2 WO 6 NPs)被加载到活性氧(ROS)反应性血小板膜(PMs)中以形成杂化体(PM-BiW NPs)。PMs上的P-选择素赋予PM-BiW NP对癌细胞的选择性。一旦进入肿瘤,激光照射就会刺激Bi 2 WO 6。NP通过光热和光动力作用产生大量的羟基自由基。这些羟基自由基在电离辐射的帮助下帮助PM破裂并减轻缺氧。这有效地将肿瘤微环境重塑为不利于MDSC募集的微环境,并有助于更好的预后。为了更好地理解该机制,监测了一组标志物的表达水平。发现低氧诱导因子-1α,外核苷三磷酸二磷酸水解酶2和腺苷5磷酸的下调是MDSCs渗透受阻的原因。该平台策略提供了一种有前途的方法,可通过三模式疗法克服由MDSC引起的免疫抑制,该疗法将光热疗法和光动力疗法的功能与放射疗法相结合。
更新日期:2020-04-06
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