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Zinc ameliorates human aortic valve calcification through GPR39 mediated ERK1/2 signalling pathway
Cardiovascular Research ( IF 10.8 ) Pub Date : 2020-04-07 , DOI: 10.1093/cvr/cvaa090 Ziying Chen 1 , Flora Gordillo-Martinez 1 , Lei Jiang 2 , Pengcheng He 3 , Wanzi Hong 3 , Xuebiao Wei 3 , Katherine A Staines 4 , Vicky E Macrae 5 , Chunxiang Zhang 6 , Danqing Yu 3 , Xiaodong Fu 1 , Dongxing Zhu 1
Cardiovascular Research ( IF 10.8 ) Pub Date : 2020-04-07 , DOI: 10.1093/cvr/cvaa090 Ziying Chen 1 , Flora Gordillo-Martinez 1 , Lei Jiang 2 , Pengcheng He 3 , Wanzi Hong 3 , Xuebiao Wei 3 , Katherine A Staines 4 , Vicky E Macrae 5 , Chunxiang Zhang 6 , Danqing Yu 3 , Xiaodong Fu 1 , Dongxing Zhu 1
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Calcific aortic valve disease (CAVD) is the most common heart valve disease in the Western world. It has been reported that zinc is accumulated in calcified human aortic valves. However, whether zinc directly regulates CAVD is yet to be elucidated. The present study sought to determine the potential role of zinc in the pathogenesis of CAVD.
中文翻译:
锌通过 GPR39 介导的 ERK1/2 信号通路改善人主动脉瓣钙化
钙化性主动脉瓣疾病 (CAVD) 是西方世界最常见的心脏瓣膜疾病。据报道,锌在钙化的人主动脉瓣中积累。然而,锌是否直接调节 CAVD 尚待阐明。本研究试图确定锌在 CAVD 发病机制中的潜在作用。
更新日期:2020-04-07
中文翻译:
锌通过 GPR39 介导的 ERK1/2 信号通路改善人主动脉瓣钙化
钙化性主动脉瓣疾病 (CAVD) 是西方世界最常见的心脏瓣膜疾病。据报道,锌在钙化的人主动脉瓣中积累。然而,锌是否直接调节 CAVD 尚待阐明。本研究试图确定锌在 CAVD 发病机制中的潜在作用。