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Compartmentalized processing of catechols during mussel byssus fabrication determines the destiny of DOPA [Biochemistry]
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2020-04-07
Tobias Priemel, Ranveer Palia, Margaryta Babych, Christopher J. Thibodeaux, Steve Bourgault, Matthew J. Harrington

Inspired largely by the role of the posttranslationally modified amino acid dopa (DOPA) in mussel adhesion, catechol functional groups have become commonplace in medical adhesives, tissue scaffolds, and advanced smart polymers. Yet, the complex redox chemistry of catechol groups complicates cross-link regulation, hampering fabrication and the long-term stability/performance of mussel-inspired...

中文翻译:

贻贝制造过程中对儿茶酚的分区处理决定了DOPA的命运[生物化学]

很大程度上受到翻译后修饰的氨基酸多巴(贻贝)在贻贝粘附中的作用的启发,儿茶酚官能团已在医用粘合剂,组织支架和高级智能聚合物中变得司空见惯。然而,邻苯二酚基团的复杂氧化还原化学使交联调节变得复杂,阻碍了贻贝类药物的制备和长期稳定性/性能。
更新日期:2020-04-08
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