The Saccharomyces cerevisiae protein Ddi1 and its homologs in higher eukaryotes have been proposed to serve as shuttling factors that deliver ubiquitinated substrates to the proteasome. Although Ddi1 contains both ubiquitin-interacting UBA and proteasome-interacting UBL domains, the UBL domain is atypical, as it binds ubiquitin. Furthermore, unlike other shuttling factors,...

中文翻译：

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Ddi1是一种泛素依赖性蛋白酶[生物化学]

酿酒酵母蛋白Ddi1及其在高等真核生物中的同源物已被提议作为穿梭因子，可将泛素化的底物递送至蛋白酶体。尽管Ddi1同时包含与泛素相互作用的UBA和与蛋白酶体相互作用的UBL结构域，但UBL结构域是非典型的，因为它与泛素结合。此外，与其他穿梭因素不同，...