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Coordination of mRNA and tRNA methylations by TRMT10A [Biochemistry]
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2020-04-07 R. Jordan Ontiveros, Hui Shen, Julian Stoute, Amber Yanas, Yixiao Cui, Yuyu Zhang, Kathy Fange Liu
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2020-04-07 R. Jordan Ontiveros, Hui Shen, Julian Stoute, Amber Yanas, Yixiao Cui, Yuyu Zhang, Kathy Fange Liu
The posttranscriptional modification of messenger RNA (mRNA) and transfer RNA (tRNA) provides an additional layer of regulatory complexity during gene expression. Here, we show that a tRNA methyltransferase, TRMT10A, interacts with an mRNA demethylase FTO (ALKBH9), both in vitro and inside cells. TRMT10A installs N1-methylguanosine (m1G) in tRNA, and FTO...
中文翻译：
TRMT10A协调mRNA和tRNA甲基化[生物化学]
信使RNA（mRNA）和转移RNA（tRNA）的转录后修饰在基因表达过程中提供了另一层调控复杂性。在这里，我们显示了在体外和细胞内，tRNA甲基转移酶TRMT10A与mRNA脱甲基酶FTO（ALKBH9）相互作用。TRMT10A在tRNA中安装了N1-甲基鸟苷（m1G），FTO ...
更新日期：2020-04-08
中文翻译：
TRMT10A协调mRNA和tRNA甲基化[生物化学]
信使RNA（mRNA）和转移RNA（tRNA）的转录后修饰在基因表达过程中提供了另一层调控复杂性。在这里，我们显示了在体外和细胞内，tRNA甲基转移酶TRMT10A与mRNA脱甲基酶FTO（ALKBH9）相互作用。TRMT10A在tRNA中安装了N1-甲基鸟苷（m1G），FTO ...
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