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The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens [Biochemistry]
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2020-04-07
Ernst R. Werner, Markus A. Keller, Sabrina Sailer, Katharina Lackner, Jakob Koch, Martin Hermann, Stefan Coassin, Georg Golderer, Gabriele Werner-Felmayer, Raphael A. Zoeller, Nicolas Hulo, Johannes Berger, Katrin Watschinger

A significant fraction of the glycerophospholipids in the human body is composed of plasmalogens, particularly in the brain, cardiac, and immune cell membranes. A decline in these lipids has been observed in such diseases as Alzheimer’s and chronic obstructive pulmonary disease. Plasmalogens contain a characteristic 1-O-alk-1′-enyl ether (vinyl ether) double...

中文翻译:

TMEM189基因编码缩醛乙醇胺去饱和酶,该酶将特征性的乙烯基醚双键引入缩醛磷脂[生物化学]

人体中很大一部分的甘油磷脂由缩醛磷脂组成,尤其是在脑,心脏和免疫细胞膜中。在诸如阿尔茨海默氏病和慢性阻塞性肺病的疾病中已经观察到这些脂质的下降。疟原虫含有特征性的1-O-alk-1'-烯基醚(乙烯基醚)双...
更新日期:2020-04-08
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