The yeast prion protein Sup35, which contains intrinsically disordered regions, forms amyloid fibrils responsible for a prion phenotype [PSI+]. Using high-speed atomic force microscopy (HS-AFM), we directly visualized the prion determinant domain (Sup35NM) and the formation of its oligomers and fibrils at subsecond and submolecular resolutions. Monomers with freely moving...

中文翻译：

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高速原子力显微镜观察酵母yeast蛋白Sup35形成寡聚物和淀粉样蛋白原纤维的动力学[生物物理学和计算生物学]

含有内在无序区域的酵母intrinsic病毒蛋白Sup35形成了导致a病毒表型[PSI +]的淀粉样原纤维。使用高速原子力显微镜（HS-AFM），我们可以直观地看到and病毒决定簇（Sup35NM）及其在亚秒和亚分子分辨率下的低聚物和原纤维的形成。自由移动的单体...