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Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities [Chemistry]
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2020-04-07
Milena Schuhmacher, Andreas T. Grasskamp, Pavel Barahtȷan, Nicolai Wagner, Benoit Lombardot, Jan S. Schuhmacher, Pia Sala, Annett Lohmann, Ian Henry, Andreȷ Shevchenko, Unal Coskun, Alexander M. Walter, Andre Nadler

Every cell produces thousands of distinct lipid species, but insight into how lipid chemical diversity contributes to biological signaling is lacking, particularly because of a scarcity of methods for quantitatively studying lipid function in living cells. Using the example of diacylglycerols, prominent second messengers, we here investigate whether lipid chemical...

中文翻译:

活细胞脂质生物化学揭示了二酰基甘油侧链组成对细胞脂质动力学和蛋白质亲和力的作用[化学]

每个细胞产生数千种不同的脂质种类,但缺乏关于脂质化学多样性如何促进生物信号传导的见解,尤其是因为缺乏定量研究活细胞中脂质功能的方法。以主要的第二信使甘油二酰基甘油为例,我们在这里研究脂质化学物质是否...
更新日期:2020-04-08
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