Several studies have suggested that drug resistance in colon cancer patients with diabetes may be associated with long‐term insulin administration, which in turn decreases the survival rate. Metformin is a commonly used drug to treat diabetes but has been recently demonstrated to have a potential therapeutic effect on colon cancer. This study aimed to elucidate the underlying mechanism by which metformin reverts insulin‐induced oxaliplatin resistance in human colon cancer HCT116 cells.

中文翻译：

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二甲双胍通过激活人结肠癌HCT116细胞中的线粒体凋亡途径来恢复胰岛素诱导的奥沙利铂耐药性。

多项研究表明，结肠癌糖尿病患者的耐药性可能与长期服用胰岛素有关，从而降低了生存率。二甲双胍是治疗糖尿病的常用药物，但最近已证明对结肠癌具有潜在的治疗作用。这项研究旨在阐明二甲双胍逆转人结肠癌HCT116细胞中胰岛素诱导的奥沙利铂耐药性的潜在机制。