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Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate Osteoarthritis.
Arthritis & Rheumatology ( IF 13.3 ) Pub Date : 2020-04-05 , DOI: 10.1002/art.41250 Alexander E Weber 1 , Omid Jalali 1 , Sean Limfat 1 , Ruzanna Shkhyan 1 , Robert Van Der Horst 1 , Siyoung Lee 1 , Yucheng Lin 2 , Liangliang Li 3 , Erik N Mayer 1 , Liming Wang 4 , Nancy Q Liu 1 , Frank A Petrigliano 1 , Jay R Lieberman 1 , Denis Evseenko 1
Arthritis & Rheumatology ( IF 13.3 ) Pub Date : 2020-04-05 , DOI: 10.1002/art.41250 Alexander E Weber 1 , Omid Jalali 1 , Sean Limfat 1 , Ruzanna Shkhyan 1 , Robert Van Der Horst 1 , Siyoung Lee 1 , Yucheng Lin 2 , Liangliang Li 3 , Erik N Mayer 1 , Liming Wang 4 , Nancy Q Liu 1 , Frank A Petrigliano 1 , Jay R Lieberman 1 , Denis Evseenko 1
Affiliation
Inhibition of hedgehog (HH) signaling prevents cartilage degeneration and promotes repair in animal models of osteoarthritis (OA). This study, undertaken in OA models and in human OA articular cartilage, was designed to explore whether kappa opioid receptor (KOR) modulation via the inhibition of HH signaling may have therapeutic potential for achieving disease‐modifying activity in OA.
中文翻译：
Kappa 阿片类药物对 Hedgehog 信号传导的调节以减轻骨关节炎。
在骨关节炎 (OA) 动物模型中，抑制刺猬 (HH) 信号可防止软骨退化并促进修复。这项在 OA 模型和人类 OA 关节软骨中进行的研究旨在探索通过抑制 HH 信号传导来调节 kappa 阿片受体 (KOR) 是否具有在 OA 中实现疾病缓解活性的治疗潜力。
更新日期：2020-04-05
中文翻译：
Kappa 阿片类药物对 Hedgehog 信号传导的调节以减轻骨关节炎。
在骨关节炎 (OA) 动物模型中，抑制刺猬 (HH) 信号可防止软骨退化并促进修复。这项在 OA 模型和人类 OA 关节软骨中进行的研究旨在探索通过抑制 HH 信号传导来调节 kappa 阿片受体 (KOR) 是否具有在 OA 中实现疾病缓解活性的治疗潜力。
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