Betalactam (BL) antibiotics are the most common cause of drug hypersensitivity. Amoxicillin (AX), which is often prescribed alongside clavulanic acid (Clav), is the most common elicitor. The aim of this study was to determine whether AX and Clav‐responsive T‐cells are detectable in patients with immediate hypersensitivity to AX‐Clav, to assess whether these T‐cells display the same specificity as that detected in skin and provocation testing, and to explore T‐cell activation pathways.

中文翻译：

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立即药物过敏患者的阿莫西林和克拉维酸特异性 T 细胞克隆的表征

β-内酰胺 (BL) 抗生素是药物超敏反应的最常见原因。阿莫西林 (AX) 通常与克拉维酸 (Clav) 一起开处方，是最常见的诱导剂。本研究的目的是确定在对 AX-Clav 立即过敏的患者中是否可检测到 AX 和 Clav 反应性 T 细胞，以评估这些 T 细胞是否显示出与在皮肤和激发试验中检测到的相同的特异性，以及探索 T 细胞活化途径。