Nanotechnology empowered localized cancer chemotherapy has indicated a promising performance for targeting and controlled release of anticancer agents over a period of time to eliminate local‐regional recurrence of cancers and also to improve the tissue regeneration during/after treatment. Electrospun nanofiber‐based implantable drug‐delivery systems have been established as one of the most effective approaches for localized cancer treatment, allowing the on‐site delivery of anticancer agents and reducing systemic toxicities and side effects to normal cells. The present review aimed to summarize the latest cutting‐edge research on applications of electrospun‐based systems for local chemotherapy. Meantime, in vitro and in vivo studies conducted using various anticancer agents along with the capability of electrospun nanofibers for combinatorial/synergistic chemotherapy as well as existing challenges and the potential dramatic advances in applying this pioneering approach for clinical transition in localized treatments of cancer is also discussed.

中文翻译：

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用于局部癌症化疗的电纺纳米纤维介导的药物递送策略的最新进展。

纳米技术赋能局部癌症化疗已表明在一段时间内靶向和控释抗癌剂以消除癌症的局部区域复发并改善治疗期间/之后的组织再生具有良好的性能。基于电纺纳米纤维的可植入药物递送系统已被确立为局部癌症治疗最有效的方法之一，允许现场递送抗癌药物并减少对正常细胞的全身毒性和副作用。本综述旨在总结基于静电纺丝系统在局部化疗中应用的最新前沿研究。与此同时，