In the present study, bubble-driven magnesium-based micromotors were fabricated through a shading method, and the potential of magnetic guidance of magnesium-based Janus micro/nanomotors through functionalization with superparamagnetic iron oxide nanoparticles (SPIONs) was investigated for the first time. SPIONs had physical electrostatic attraction with the positively charged magnesium spheres due to negative charges on their surfaces. It was also found that upon applying a field gradient, the micromotors’ velocity increased by 13% unlike other magnetically navigated spherical magnesium-based micromotors which only show a change in direction. In this work the cytotoxicity of the moving magnesium-based micromotors was investigated for the first time and their cell viability corresponding to 100 μg ml⁻¹ was nearly 80%. Also, an antibacterial drug molecule was attached to the surfaces of the micromotors through direct conjugation. The drug attachment was confirmed by FTIR analysis and the drug loading capacity was also measured. The antibacterial activity of the moving micromotors reached nearly 100% in in vitro medium through drug conjugation. Furthermore, it was shown that their motile state was more bactericidal compared with their static state.

中文翻译：

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能够磁导航和掺入抗生素的镁基Janus微电机的合成

在本研究中，通过阴影法制造了气泡驱动的镁基微电机，并且首次研究了通过超顺磁性氧化铁纳米粒子（SPIONs）的功能化对镁基Janus微/纳米电机的磁导潜力。SPIONs由于其表面带有负电荷而与带正电的镁球具有物理静电吸引。还发现，在施加场梯度时，微电机的速度增加了13％，这与其他磁导航球形镁基微电机不同，后者仅显示方向变化。在这项工作中，首次研究了移动镁基微电机的细胞毒性，其细胞活力对应于100μgml ^-1是将近80％。另外，抗菌药物分子通过直接结合而附着在微马达的表面上。通过FTIR分析确认了药物附着，并且还测量了药物载量。通过药物结合，运动的微电机在体外培养基中的抗菌活性达到近100％。此外，显示出它们的运动状态与其静态相比具有更多的杀菌作用。