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Development of new self-assembled cationic amino liposomes for efficient gene delivery.
Biomaterials Science ( IF 6.6 ) Pub Date : 2020-04-06 , DOI: 10.1039/d0bm00331j Yihang Wu 1 , Yue Xiong , Ling Wang , Quanming Zhou , Linxian Li , Pavel A Levkin , Gary Davidson , Liqian Gao , Wenbin Deng
Biomaterials Science ( IF 6.6 ) Pub Date : 2020-04-06 , DOI: 10.1039/d0bm00331j Yihang Wu 1 , Yue Xiong , Ling Wang , Quanming Zhou , Linxian Li , Pavel A Levkin , Gary Davidson , Liqian Gao , Wenbin Deng
Affiliation
A library of 83 structurally diverse cationic amino liposomes is rationally designed and parallelly synthesized for the transfection of plasmid DNA and siRNA. Our designed self-assembled liposomes not only exhibit excellent transfection efficiency in HEK 293T cells and mouse embryonic stem cells, but also show low cytotoxicity.
中文翻译:
新型自组装阳离子氨基脂质体的开发,可有效传递基因。
合理设计并并行合成了83种结构多样的阳离子氨基脂质体的文库,用于转染质粒DNA和siRNA。我们设计的自组装脂质体不仅在HEK 293T细胞和小鼠胚胎干细胞中表现出出色的转染效率,而且还显示出低细胞毒性。
更新日期:2020-04-06
中文翻译:
新型自组装阳离子氨基脂质体的开发,可有效传递基因。
合理设计并并行合成了83种结构多样的阳离子氨基脂质体的文库,用于转染质粒DNA和siRNA。我们设计的自组装脂质体不仅在HEK 293T细胞和小鼠胚胎干细胞中表现出出色的转染效率,而且还显示出低细胞毒性。