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O-linked β-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1.
PLOS Genetics ( IF 4.5 ) Pub Date : 2020-04-06 , DOI: 10.1371/journal.pgen.1008730
Yongxin Mu 1 , Houzhi Yu 1, 2 , Tongbin Wu 1 , Jianlin Zhang 1 , Sylvia M Evans 1, 3 , Ju Chen 1
Affiliation  

O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) is the only enzyme catalyzing O-GlcNAcylation. Although it has been shown that OGT plays an essential role in maintaining postnatal heart function, its role in heart development remains unknown. Here we showed that loss of OGT in early fetal cardiomyocytes led to multiple heart developmental defects including hypertrabeculation, biventricular dilation, atrial septal defects, ventricular septal defects, and defects in coronary vessel development. In addition, RNA sequencing revealed that Angiopoietin-1, required within cardiomyocytes for both myocardial and coronary vessel development, was dramatically downregulated in cardiomyocyte-specific OGT knockout mouse hearts. In conclusion, our data demonstrated that OGT plays an essential role in regulating heart development through activating expression of cardiomyocyte Angiopoietin-1.

中文翻译:

O-连接的 β-N-乙酰葡糖胺转移酶通过调节血管生成素-1 在心脏发育中发挥重要作用。

O-连接的 N-乙酰葡糖胺 (GlcNAc) 转移酶 (OGT) 是唯一催化 O-GlcNAcylation 的酶。尽管已经证明 OGT 在维持产后心脏功能方面起着重要作用,但它在心脏发育中的作用仍然未知。在这里,我们发现早期胎儿心肌细胞中 OGT 的缺失导致多种心脏发育缺陷,包括小梁过度形成、双心室扩张、房间隔缺损、室间隔缺损和冠状血管发育缺陷。此外,RNA 测序显示,心肌细胞内心肌和冠状血管发育所需的 Angiopoietin-1 在心肌细胞特异性 OGT 基因敲除小鼠心脏中显着下调。综上所述,
更新日期:2020-04-06
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