Adrenocortical carcinomas are devastating cancers, expressing high levels of glutathione peroxidase 4 (GPX4). Therefore, it was recently suggested that these tumors might be therapeutically targeted by inducing ferroptosis. In this issue of Cell Death and Disease, Weigand et al. describe the organ-specific production of steroid hormones as a potential culprit for the exquisite sensitivity of these cancers to ferroptosis.

中文翻译：

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反正压力会杀死你！

肾上腺皮质癌是毁灭性癌症，表达高水平的谷胱甘肽过氧化物酶4（GPX4）。因此，近来有人提出，通过诱导ferroptosis可以将这些肿瘤作为治疗目标。在本期《细胞死亡与疾病》中，Weigand等人。描述类固醇激素的器官特异性产生是这些癌症对肥大病的极度敏感性的潜在元凶。