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EGFR blockade activates interferon
Nature Cancer ( IF 22.7 ) Pub Date : 2020-04-06 , DOI: 10.1038/s43018-020-0055-1 Ryohei Yoshida 1 , David A Barbie 1, 2
Nature Cancer ( IF 22.7 ) Pub Date : 2020-04-06 , DOI: 10.1038/s43018-020-0055-1 Ryohei Yoshida 1 , David A Barbie 1, 2
Affiliation
Dysregulation of innate immune signaling in cancer can be pro-tumorigenic and can promote adaptive resistance to targeted therapies. Type I interferon signaling is now shown to promote survival following inhibition of the kinase EGFR, even in cells that are not ‘addicted’ to EGFR signaling.
中文翻译:
EGFR阻断激活干扰素
癌症中先天免疫信号的失调可能是促肿瘤发生的,并且可以促进对靶向治疗的适应性抵抗。现在显示 I 型干扰素信号传导可促进激酶 EGFR 抑制后的存活,即使在对 EGFR 信号传导不“上瘾”的细胞中也是如此。
更新日期:2020-04-24
中文翻译:
EGFR阻断激活干扰素
癌症中先天免疫信号的失调可能是促肿瘤发生的,并且可以促进对靶向治疗的适应性抵抗。现在显示 I 型干扰素信号传导可促进激酶 EGFR 抑制后的存活,即使在对 EGFR 信号传导不“上瘾”的细胞中也是如此。