Abstract—

The design of individual elements of an improved system for laser fluorescence spectroscopy in vivo is described. The proposed technical solutions, in particular, the inclusion of a white light source in the system and the special design of the fiber optic probe and filter unit allow elimination of a number of drawbacks of the existing systems. In the described system, the diffuse reflection spectrum of the studied region is determined automatically after detecting the fluorescence spectra. The equality of the diagnostic volumes is achieved not only by automatically switching modes, but also by using a large number of lighting fibers located around the receiving fiber to uniformly illuminate the area of interest. The design of the filter unit, which allows one to adjust the transfer function of the device by adjusting the degree of overlap of the light beam by the filter, is shown. We believe that the inclusion of these elements in systems of laser fluorescence spectroscopy will make it possible to refine this method, unify the parameters of similar devices, and configure all devices in an identical way in the future.

中文翻译：

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一种改进的医学体内荧光分析系统

摘要-

描述了用于体内激光荧光光谱的改进系统的各个元件的设计。所提出的技术解决方案，特别是在系统中包括白光源以及光纤探头和滤光器单元的特殊设计，可以消除现有系统的许多缺点。在所描述的系统中，在检测荧光光谱之后自动确定研究区域的漫反射光谱。诊断体积的相等性不仅可以通过自动切换模式来实现，还可以通过使用位于接收光纤周围的大量照明光纤来均匀照明感兴趣区域来实现。过滤单元的设计 示出了通过调节滤光片的光束的重叠程度来允许调节器件的传递函数的装置。我们相信，将这些元素包含在激光荧光光谱系统中将使将来有可能改进此方法，统一相似设备的参数并以相同方式配置所有设备。