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Electrochemical behavior of 5-type phosphodiesterase inhibitory drugs in solid state by voltammetry of immobilized microparticles
Journal of Solid State Electrochemistry ( IF 2.5 ) Pub Date : 2020-04-06 , DOI: 10.1007/s10008-020-04533-1
Géssica Domingos da Silveira , Lucas Panes Bressan , Marcella Emilia Petra Schmidt , Thaís Ramos Dal Molin , Carlos Alberto Teixeira , Ronei Jesus Poppi , José Alberto Fracassi da Silva

Evaluation of electrochemical behavior of 5-type phosphodiesterase inhibitory drugs is of major concern since they have been added illegally as adulterants in dietary supplements. Then, for the first time, the solid-sate electrochemistry of sildenafil and tadalafil is described using voltammetry of immobilized microparticles (VIMP). An electrochemical cell was designed and printed in a fused deposition modeling (FDM)-based 3D printer for VIMP measurements. The 3D-printed cell designed with a distance of 5 mm between the working and reference electrode presented better voltammetric response and decrease in the uncompensated resistance of the electrochemical system. Cyclic and square wave voltammograms of the individual compounds were recorded in a paraffin-impregnated graphite electrode in contact with 0.01 mol L−1 H2SO4. The electrochemical oxidation/reduction products were characterized by Raman spectroscopy and scanning electron microscopy (SEM). Different voltammetric responses were detected for the solid compounds depending on the solubility of the parent compound and their products of oxidation/reduction. Moreover, significant crystal re-structuring was also observed after voltammetric scan of the solid compounds. Under optimized conditions, sildenafil and tadalafil could be electrochemical identified and distinguished in dietary supplements.



中文翻译:

固定化微粒伏安法测定固态5型磷酸二酯酶抑制剂的电化学行为

对5型磷酸二酯酶抑制药物的电化学行为的评估是主要关注的问题,因为它们已作为掺假品非法添加到膳食补充剂中。然后,首次使用固定化微粒的伏安法(VIMP)描述了西地那非和他达拉非的固体电解质。设计了电化学电池,并在基于熔融沉积建模(FDM)的3D打印机中进行了打印,以进行VIMP测量。设计的3D打印电池在工作电极和参比电极之间的距离为5 mm,表现出更好的伏安响应,并降低了电化学系统的未补偿电阻。在与0.01 mol L -1接触的石蜡浸渍的石墨电极中记录各个化合物的循环伏安和方波伏安图H 2 SO 4。电化学氧化/还原产物通过拉曼光谱和扫描电子显微镜(SEM)表征。根据母体化合物的溶解度及其氧化/还原产物,检测到了不同的固体化合物伏安响应。此外,在固体化合物的伏安扫描之后,还观察到明显的晶体重构。在最佳条件下,西地那非和他达拉非可以在膳食补充剂中进行电化学鉴定和区分。

更新日期:2020-04-06
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