This work presents the development and characterization of an electrochemical sensor of tin hexacyanoferrate (SnHCF), produced from the modification by drop casting of the boron-doped diamond electrode (BDD), and its subsequent evaluation in the determination of dopamine (DP) in a synthetic saliva sample. The sensors, BDD-SnHCF and unmodified BDD, were characterized by atomic force microscopy (AFM), scanning electron microscopy (SEM), and electrochemical impedance spectroscopy, where the BDD-SnHCF presented higher roughness and lower resistance to electronic transfer. Raman spectroscopy and energy-dispersive X-ray spectroscopy (EDS) were used to confirm the chemical composition and bonding of the SnHCF film. The electroactive area and the heterogeneous electron transfer rate constant (k₀) presented higher values for BDD-SnHCF. Analytical curves were constructed, by batch injection analysis (BIA) with amperometric detection (BIA-AMP), and the slope obtained for BDD-SnHCF was significantly higher when compared with unmodified BDD. The detection limit for BDD-SnHCF (0.21 μmol L⁻¹) presented a value sevenfold lower than unmodified BDD and good analytical frequency (72 h⁻¹) obtained for the modified electrode. The determination of DP in saliva, as a proof-of-concept, achieved an excellent accuracy, reported by a recovery of (90% ± 8) in the sample. The results showed that SnHCF is an interesting alternative for the BDD drop casting modification, presenting a significant improvement in the electrochemical characteristics and analytical performance of DP in the determination by BIA-AMP compared with unmodified BDD.

这项工作介绍了六氰合铁酸锡（SnHCF）电化学传感器的开发和特性，该传感器是通过滴铸掺杂硼的金刚石电极（BDD）进行修饰而制得的，并随后对其在测定多巴胺（DP）中的评估进行了评估。合成唾液样品。传感器BDD-SnHCF和未修饰的BDD通过原子力显微镜（AFM），扫描电子显微镜（SEM）和电化学阻抗谱进行了表征，其中BDD-SnHCF呈现出更高的粗糙度和更低的电子传递阻力。拉曼光谱和能量色散X射线光谱法（EDS）用于确认SnHCF膜的化学成分和结合。电活性面积和异质电子传递速率常数（k ₀）呈现出更高的BDD-SnHCF值。通过批量注入分析（BIA）和安培检测（BIA-AMP）构建了分析曲线，与未经修饰的BDD相比，BDD-SnHCF的斜率明显更高。BDD-SnHCF的检出限（0.21μmolL ^-1）的值比未修饰的BDD低7倍，并且分析频率良好（72 h ^-1）获得的修饰电极。作为概念证明，唾液中DP的测定获得了极好的准确性，据报道样品中的回收率为（90％±8）。结果表明，SnHCF是BDD滴铸法修饰的有趣替代品，与未修饰的BDD相比，BIA-AMP测定的DP的电化学特性和分析性能显着提高。