当前位置: X-MOL 学术Int. J. Clin. Oncol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
ACO2 and ANPEP as novel prognostic markers for gallbladder squamous cell/adenosquamous carcinomas and adenocarcinomas.
International Journal of Clinical Oncology ( IF 3.3 ) Pub Date : 2020-04-05 , DOI: 10.1007/s10147-020-01651-8
Ziru Liu 1 , Zhulin Yang 2 , Li Xiong 2 , Daiqiang Li 3 , Qiong Zou 4 , Yuan Yuan 4
Affiliation  

Background

Squamous cell/adenosquamous carcinoma (SC/ASC) is a rarely identified form of gallbladder cancer with poorly understood clinical features. As such, there is an urgent need to identify novel prognostic biomarkers for such gallbladder SC/ASC cases, and for gallbladder adenocarcinomas (ACs).

Methods

The levels of ACO2 and ANPEP proteins were assessed via an EnVision-based immunohistochemical approach using 46 SC/ASC and 80 AC patient samples.

Results

There was a marked reduction in levels of ACO2 and ANPEP in gallbladder AC relative to normal adjacent tissue or benign gallbladder lesions. The was a significant correlation between lack of ACO2 and ANPEP and larger tumors, higher tumor-node-metastasis (TNM) staging, invasion, metastasis to regional lymph nodes, and ineligibility for surgical resection in both SC/ASC and AC tumor samples. Kaplan–Meier survival analyses further confirmed a relationship between ACO2 and ANPEP negativity and decreased overall survival in patients with these diseases (p < 0.05 or p < 0.01), and a multivariate regression analysis further established that ACO2 negativity and ANPEP negativity were independently predictive of poor SC/ASC and AC patient outcomes.

Conclusions

ACO2 and ANPEP may have key physiological relevance in cancers of the gallbladder and thus warrant investigation as prognostic biomarkers.



中文翻译:

ACO2和ANPEP作为胆囊鳞状细胞/腺鳞癌和腺癌的新的预后标志物。

背景

鳞状细胞癌/腺鳞癌(SC / ASC)是一种鲜为人知的胆囊癌形式,临床特征尚不清楚。因此,迫切需要为此类胆囊SC / ASC病例和胆囊腺癌(AC)鉴定新的预后生物标记物。

方法

通过基于EnVision的免疫组织化学方法,使用46个SC / ASC和80个AC患者样品,评估了ACO2和ANPEP蛋白的水平。

结果

与正常的邻近组织或良性胆囊病变相比,胆囊AC中ACO2和ANPEP的水平明显降低。缺乏ACO2和ANPEP与更大的肿瘤,更高的肿瘤淋巴结转移(TNM)分期,侵袭,转移至局部淋巴结以及不适合进行SC / ASC和AC肿瘤标本的手术切除之间存在显着相关性。Kaplan-Meier生存分析进一步证实了这些疾病患者的ACO2和ANPEP阴性之间的关系以及总体生存率的降低(p  <0.05或p  <0.01),并且多元回归分析进一步确定了ACO2阴性和ANPEP阴性可以独立预测SC / ASC和AC患者预后不良。

结论

ACO2和ANPEP在胆囊癌中可能具有关键的生理相关性,因此有必要作为预后生物标志物进行研究。

更新日期:2020-04-21
down
wechat
bug