Helicobacter pylori is a pathogen responsible for peptic ulcers and gastric cancers in human. One of the unique biological features of this bacterium is a membrane lipid composition significantly differed from that of typical Gram-negative bacteria. Due to its unique lipid composition, the responses of H. pylori to various exogenous lipophilic compounds significantly differ from the responses of typical Gram-negative bacteria to the same lipophilic compounds. For instance, some steroidal compounds are incorporated into the biomembranes of H. pylori through the intermediation of the myristoyl-phosphatidylethanolamine (PE). In addition, H. pylori shows high susceptibility to bacteriolytic action of lipids such as 3-carbonyl steroids, vitamin D, and indene compounds. These lipids are also considered to interact with myristoyl-PE of H. pylori membranes, and to ultimately confer the bactericidal action to this bacterium. In this study we summarize the lipids concerned with H. pylori and suggest the possibility of the development of chemotherapeutic medicines that act on the membrane lipid component of H. pylori.

中文翻译：

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幽门螺杆菌对外源性疏水化合物的独特反应。

幽门螺杆菌是引起人类消化性溃疡和胃癌的病原体。该细菌独特的生物学特征之一是膜脂质成分与典型的革兰氏阴性细菌明显不同。由于其独特的脂质组成，幽门螺杆菌对各种外源性亲脂性化合物的反应与典型的革兰氏阴性细菌对相同的亲脂性化合物的反应显着不同。例如，一些甾族化合物通过肉豆蔻酰基磷脂酰乙醇胺（PE）的中介作用被引入幽门螺杆菌的生物膜中。另外，幽门螺杆菌显示出对诸如3-羰基类固醇，维生素D和茚化合物的脂质的细菌分解作用的高度敏感性。这些脂质也被认为与H的肉豆蔻酰-PE相互作用。幽门螺杆菌膜，并最终赋予该细菌杀菌作用。在这项研究中，我们总结了与幽门螺杆菌有关的脂质，并提出了发展作用于幽门螺杆菌膜脂质成分的化学治疗药物的可能性。