Epigenetics has been discussed as a potential factor influencing the pathophysiology and severity of inflammatory skin diseases. In recent years, emerging evidence suggests that epigenetic mechanisms are involved in the pathophysiology of not only atopic dermatitis (AD) and psoriasis (PSO) but also lupus erythematosus and oral lichen. A systematic review of the literature was undertaken to provide an unbiased and comprehensive update on the involvement of methylation patterns in inflammatory skin disease. In addition to reviewing the contribution of epigenetic mechanisms regulating the development of inflammatory skin diseases, this review aimed to discern the overlap of epigenetic risk factors of the 2 most common inflammatory skin diseases, AD and PSO. Although AD and PSO are both inflammatory skin diseases, both show a distinct genetic profile. Herein, we give evidence that both AD and PSO share epigenetic risk factors that might contribute to disease characteristics. We identify a core subset of inflammation-associated differentially methylated genes in both AD and PSO and discuss the association in other inflammatory diseases.

已经讨论了表观遗传学作为影响炎症性皮肤病的病理生理和严重性的潜在因素。近年来，越来越多的证据表明表观遗传机制不仅参与特应性皮炎（AD）和牛皮癣（PSO）的病理生理，而且还参与红斑狼疮和口腔地衣的病理生理。对文献进行了系统的综述，以提供有关甲基化模式参与炎症性皮肤病的公正而全面的更新。除了综述表观遗传机制调节炎症性皮肤病发展的作用外，本综述还旨在辨别两种最常见的炎症性皮肤病（AD和PSO）的表观遗传危险因素的重叠。尽管AD和PSO都是炎性皮肤疾病，但两者均显示出独特的遗传特征。在本文中，我们提供的证据表明，AD和PSO均具有可能会导致疾病特征的表观遗传危险因素。我们确定在AD和PSO中炎症相关的差异甲基化基因的核心子集，并讨论在其他炎症疾病中的关联。