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Age inappropriate influenza vaccination in infants less than 6 months old, 2010-2018.
Vaccine ( IF 5.5 ) Pub Date : 2020-04-06 , DOI: 10.1016/j.vaccine.2020.03.039
Tiffany A Suragh 1 , Beth Hibbs 1 , Paige Marquez 1 , Michael M McNeil 1
Affiliation  

BACKGROUND Annual influenza vaccination is recommended for persons 6 months or older and vaccination in infants less than 6 months old is a vaccine administration error. There are limited safety studies in this population, particularly among infants less than 6 weeks old. METHODS We searched the U.S. Vaccine Adverse Event Reporting System (VAERS) database for reports of adverse events (AEs) following influenza vaccination in infants less than 6 months old for the 2010-2018 influenza seasons. We conducted a descriptive and qualitative analysis of reports to describe AEs and identify possible risk factors. RESULTS In total, 114 reports were identified; only 21 reported a specific AE. Pyrexia, irritability, crying and diarrhea were the most common symptoms. There were 12 reports involving newborns; the most common circumstance cited was confusion with the birth dose of hepatitis B vaccine. The following risk factors were identified: (1) individuals getting vaccinated together resulting in patient mix-ups; (2) healthcare provider not verifying the patient's information; (3) individual provider confusion due to similarities in vaccines' packaging and names of vaccines that sound alike. CONCLUSIONS Reports identified of influenza vaccination in infants less than 6 months old indicate that vaccination errors in this age group are occurring and healthcare providers who vaccinate infants should be aware of how to prevent such events. Our study adds to the existing literature by providing valuable information regarding the general absence of serious adverse events in the case of vaccination errors associated with inadvertent influenza vaccine within this population.

中文翻译:

2010-2018年之间6个月以下婴儿的年龄不当流感疫苗接种情况。

背景技术建议对6个月以上的人进行年度流感疫苗接种,而对6个月以下的婴儿进行疫苗接种是疫苗接种的错误。此人群的安全性研究有限,尤其是在6周以下的婴儿中。方法我们在美国疫苗不良事件报告系统(VAERS)数据库中搜索了2010-2018年流感季节不到6个月大的婴儿进行流感疫苗接种后的不良事件(AE)报告。我们对报告进行了描述性和定性分析,以描述不良事件并确定可能的风险因素。结果总共确定了114份报告;只有21个报告了特定的AE。发热,烦躁,哭闹和腹泻是最常见的症状。有12例新生儿报告。最常见的情况是与乙型肝炎疫苗的出生剂量混淆。确定了以下风险因素:(1)个人一起接种疫苗,导致患者混淆。(2)医疗保健提供者未核实患者信息;(3)由于疫苗包装和听起来相似的疫苗名称的相似性,个人提供者感到困惑。结论在6个月以下的婴儿中已确认进行流感疫苗接种的报告表明,该年龄组正在发生疫苗接种错误,为婴儿接种疫苗的医疗保健提供者应了解如何预防此类事件。
更新日期:2020-04-06
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