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Metabolomic insights into the lasting impacts of early-life exposure to BDE-47 in mice.
Environmental Pollution ( IF 8.9 ) Pub Date : 2020-04-04 , DOI: 10.1016/j.envpol.2020.114524
Yuqian Li 1 , Nanyang Yu 1 , Meiying Li 1 , Kan Li 1 , Wei Shi 1 , Hongxia Yu 1 , Si Wei 1
Affiliation  

Early-life exposure to toxicants may have lasting effects that adversely impact later development. Thus, although the production and use of a toxicant have been banned, the risk to previously exposed individuals may continue. BDE-47, a component of commercial penta-BDEs, is a persistent organic pollutant with demonstrated neurotoxicity. To investigate the persistent effects of BDE-47 and the mechanisms thereof, we employed a metabolomics approach to analyze the brain, blood and urine of mice exposed to BDE-47 for 28 days and then 3 months post-exposure. In the brain, BDE-47 was detectable just after exposure but was below the limit of detection (LOD) 3 months later. However, the metabolomic alterations caused by early-life exposure to BDE-47 persisted. Potential biomarkers related to these alterations included phosphatidylcholine, lysophosphatidylcholine, sphingomyelin and several amino acids and biogenic amines. The metabolic pathways involved in the response to BDE-47 in the brain were mainly those related to glycerophospholipid metabolism, sphingomyelin metabolism and neurotransmitter regulation. Thus, our study demonstrates the utility of metabolomics, as the omics most closely reflecting the phenotype, in exploring the mechanisms underlying the lasting effects induced by early-life BDE-47 exposure.

中文翻译:

代谢组学洞察力,揭示了生命早期暴露于BDE-47对小鼠的持久影响。

生命早期接触毒物可能会产生持久影响,对以后的发展产生不利影响。因此,尽管已经禁止了有毒物质的生产和使用,但先前接触过的个体的危险可能会继续存在。BDE-47是商用五溴二苯醚的一种成分,是一种持久的有机污染物,具有神经毒性。为了研究BDE-47的持久作用及其机制,我们采用了代谢组学方法来分析暴露于BDE-47 28天后3个月的小鼠的大脑,血液和尿液。在大脑中,BDE-47刚暴露后即可检出,但在3个月后低于检测限(LOD)。但是,由于生命早期暴露于BDE-47而引起的代谢组学改变仍然存在。与这些改变有关的潜在生物标志物包括磷脂酰胆碱,溶血磷脂酰胆碱,鞘磷脂和几种氨基酸和生物胺。脑中对BDE-47应答的代谢途径主要与甘油磷脂代谢,鞘磷脂代谢和神经递质调节有关。因此,我们的研究表明,代谢组学作为最紧密反映表型的组学,在探索由早期BDE-47暴露引起的持久效应的潜在机制中非常有用。
更新日期:2020-04-20
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