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A biodegradable multifunctional nanofibrous membrane for periodontal tissue regeneration.
Acta Biomaterialia ( IF 9.7 ) Pub Date : 2020-04-03 , DOI: 10.1016/j.actbio.2020.03.044
Xuezhe Liu 1 , Xi He 1 , Dawei Jin 2 , Shuting Wu 2 , Hongsheng Wang 1 , Meng Yin 2 , Ali Aldalbahi 3 , Mohamed El-Newehy 3 , Xiumei Mo 1 , Jinglei Wu 4
Affiliation  

Biomaterial-based membranes represent a promising therapeutic option for periodontal diseases. Although conventional periodontal membranes function greatly in preventing the ingrowth of both fibroblasts and epithelial cells as well as connective tissues, they are not capable of promoting periodontal tissue regeneration. Here, we report a multifunctional periodontal membrane prepared by electrospinning biodegradable polymers with magnesium oxide nanoparticles (nMgO). nMgO is a light metal-based nanoparticle with high antibacterial capacity and can be fully resorbed in the body. Our results showed that incorporating nMgO into poly(L-lactic acid) (PLA)/gelatin significantly improved the overall properties of membranes, including elevated tensile strength to maintain structural stability and adjusted degradation rate to fit the time window of periodontal regeneration. Acidic degradation products of PLA were neutralized by alkaline ions from nMgO hydrolysis, ameliorating pH microenvironment beneficial for cell proliferation. In vitro studies demonstrated considerable antibacterial and osteogenic properties of nMgO-incorporated membranes that are highly valuable for periodontal regeneration. Further investigations in a rat periodontal defect model revealed that nMgO-incorporated membranes effectively guided periodontal tissue regeneration. Taken together, our data indicate that nMgO-incorporated membranes might be a promising therapeutic option for periodontal regeneration. STATEMENT OF SIGNIFICANCE: Traditional clinical treatments of periodontal diseases largely focus on the management of the pathologic processes, which cannot effectively regenerate the lost periodontal tissue. GTR, a classic method for periodontal regeneration, has shown promise in clinical practice. However, the current membranes might not fully fulfill the criteria of ideal membranes. Here, we report bioabsorbable nMgO-incorporated nanofibrous membranes prepared by electrospinning to provide an alternative for the clinical practice of GTR. The membranes not only function greatly as physical barriers but also exhibit high antibacterial and osteoinductive properties. We therefore believe that this study will inspire more practice work on the development of effective GTR membranes for periodontal regeneration.

中文翻译:

用于牙周组织再生的可生物降解的多功能纳米纤维膜。

基于生物材料的膜代表了牙周疾病的有前途的治疗选择。尽管常规的牙周膜在防止成纤维细胞和上皮细胞以及结缔组织向内生长方面起着很大的作用,但是它们不能促进牙周组织的再生。在这里,我们报告通过用氧化镁纳米粒子(nMgO)电纺生物可降解聚合物制备的多功能牙周膜。nMgO是具有高抗菌能力的轻金属基纳米颗粒,可以在体内完全吸收。我们的结果表明,将nMgO掺入聚L-乳酸(PLA)/明胶中可以显着改善膜的整体性能,包括提高的拉伸强度以保持结构稳定性,并调节降解速率以适合牙周再生的时间窗。PLA的酸性降解产物被nMgO水解产生的碱性离子中和,改善了对细胞增殖有利的pH微环境。体外研究表明,掺有nMgO的膜具有显着的抗菌和成骨特性,对于牙周再生非常有价值。在大鼠牙周缺损模型中的进一步研究表明,掺有nMgO的膜可有效地引导牙周组织再生。综上所述,我们的数据表明,掺有nMgO的膜可能是牙周再生的有前途的治疗选择。重要性声明:牙周疾病的传统临床治疗主要集中在病理过程的管理上,这不能有效地再生丢失的牙周组织。GTR是一种经典的牙周再生方法,已在临床实践中显示出希望。但是,当前的膜可能无法完全满足理想膜的标准。在这里,我们报告通过电纺丝制备的可生物吸收的掺入nMgO的纳米纤维膜,以为GTR的临床实践提供替代方案。膜不仅起到物理屏障的作用,而且还具有很高的抗菌和骨诱导特性。因此,我们相信这项研究将激发更多的实践工作,以开发有效的牙周再生GTR膜。不能有效地再生丢失的牙周组织。GTR是一种经典的牙周再生方法,已在临床实践中显示出希望。但是,当前的膜可能无法完全满足理想膜的标准。在这里,我们报告通过电纺丝制备的可生物吸收的掺入nMgO的纳米纤维膜,以为GTR的临床实践提供替代方案。膜不仅起到物理屏障的作用,而且还具有很高的抗菌和骨诱导特性。因此,我们相信这项研究将激发更多的实践工作,以开发有效的牙周再生GTR膜。不能有效地再生丢失的牙周组织。GTR是一种经典的牙周再生方法,已在临床实践中显示出希望。但是,当前的膜可能无法完全满足理想膜的标准。在这里,我们报告通过电纺丝制备的可生物吸收的掺入nMgO的纳米纤维膜,以为GTR的临床实践提供替代方案。膜不仅起到物理屏障的作用,而且还具有很高的抗菌和骨诱导特性。因此,我们相信这项研究将激发更多的实践工作,以开发有效的牙周再生GTR膜。当前的膜可能无法完全满足理想膜的标准。在这里,我们报告通过电纺丝制备的可生物吸收的掺入nMgO的纳米纤维膜,以为GTR的临床实践提供替代方案。膜不仅起到物理屏障的作用,而且还具有很高的抗菌和骨诱导特性。因此,我们相信这项研究将激发更多的实践工作,以开发有效的牙周再生GTR膜。当前的膜可能无法完全满足理想膜的标准。在这里,我们报告通过电纺丝制备的可生物吸收的掺入nMgO的纳米纤维膜,以为GTR的临床实践提供替代方案。膜不仅起到物理屏障的作用,而且还具有很高的抗菌和骨诱导特性。因此,我们相信这项研究将激发更多的实践工作,以开发有效的牙周再生GTR膜。
更新日期:2020-04-03
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