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Application of nano/microencapsulated phenolic compounds against cancer.
Advances in Colloid and Interface Science ( IF 15.6 ) Pub Date : 2020-04-04 , DOI: 10.1016/j.cis.2020.102153
Somayeh Rahaiee 1 , Elham Assadpour 2 , Afshin Faridi Esfanjani 2 , Ana Sanches Silva 3 , Seid Mahdi Jafari 2
Affiliation  

Nowadays, polyphenols as bioactive compounds are being used in producing anti-cancer drugs. Low stability against harsh environmental conditions, untargeted release, low solubility, and low absorption of pure phenolic molecules are significant barriers, which decrease the functions of polyphenols. Recently, the nanoencapsulation processes have been applied to overcome these restrictions, in which the anti-cancer activity of polyphenols has been noticeably increased. This review will focus on the anti-cancer activity of polyphenols, and the effect of loading polyphenolics into various micro/nanoencapsulation systems on their anti-cancer activity. Different encapsulation systems such as lipid and polymer based nanoparticles, and solid form of encapsulated phenolic molecules by nano-spray dryer and electrospinnig have been used for loading of polyphenols. Incorporation of phenolic molecules into various carriers inevitably increases their anti-cancer activity. Because, in this way, encapsulated cargos can provide a targeted release, which will increase the bioavailability of phenolic molecules and their functions such as absorption into cancer cell.

中文翻译:

纳米/微囊化酚类化合物在抗癌中的应用。

如今,作为生物活性化合物的多酚被用于生产抗癌药物。在苛刻的环境条件下稳定性低,无目标释放,溶解度低以及纯酚类分子的吸收率低是重要的障碍,会降低多酚的功能。近来,已经应用纳米囊化工艺来克服这些限制,其中多酚的抗癌活性已经显着提高。这篇综述将集中在多酚的抗癌活性上,以及将多酚装载到各种微/纳米囊封系统中对它们的抗癌活性的影响。不同的封装系统,例如基于脂质和聚合物的纳米颗粒,并且通过纳米喷雾干燥器和静电纺丝法以固体形式包封的酚分子被用于装载多酚。将酚类分子掺入各种载体中不可避免地增加了它们的抗癌活性。因为以这种方式封装的货物可以提供目标释放,这将增加酚类分子的生物利用度及其功能,例如吸收到癌细胞中。
更新日期:2020-04-06
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