The purinergic P2X7 receptor (P2X7R) is an adenosine triphosphate (ATP) ligand-gated cationic channel receptor. P2X7R is closely associated with various inflammatory, immune, cancer, neurological, musculoskeletal and cardiovascular disorders. P2X7R is an interesting therapeutic target as well as molecular imaging target. This brief digest highlights the radioligands targeting P2X7R recently developed in drug discovery and molecular imaging agent development.

中文翻译：

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靶向嘌呤能P2X7受体的放射性配体。

嘌呤能P2X7受体（P2X7R）是三磷酸腺苷（ATP）配体门控的阳离子通道受体。P2X7R与各种炎症，免疫，癌症，神经，肌肉骨骼和心血管疾病密切相关。P2X7R是一个有趣的治疗靶标以及分子成像靶标。此简短摘要重点介绍了在药物发现和分子显像剂开发中最近开发的靶向P2X7R的放射性配体。