Fetuin-A and adiponectin present significant associations, supported by recent evidence, with metabolic syndrome (MS) featuring hyperglycemia, central obesity and insulin resistance as the main components, but their biological functions are opposite. The aim of this study was to verify whether fetuin-A/adiponectin ratio (F/A ratio) is a more sensitive indicator for evaluation of MS than either fetuin-A or adiponectin. In this cross-sectional study, 465 elderly subjects were selected from the physical examination database. Serum levels of fetuin-A and adiponectin were measured using an enzyme-linked immunosorbent assay (ELISA) method. Spearman’s rank correlation coefficient, linear regression and logistic regression analysis were adopted to estimate the correlations of fetuin-A, adiponectin and F/A ratio with MS and its components, and receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive values of the aforesaid indices. Compared with fetuin-A or adiponectin, F/A ratio was significantly associated with all the components of MS, and this correlation was significant even after adjusting potential confounding factors (P < 0.05). Logistic regression analysis indicated that F/A ratio presented a stronger correlation with incident MS (adjusted OR: 1.466; 95% CI: 1.189–1.808) than fetuin-A (adjusted OR: 1.100; 95% CI: 1.020–1.186) and adiponectin (adjusted OR: 0.760; 95% CI: 0.664–0.871) alone. ROC analysis revealed that F/A ratio achieved a larger area under curve (AUC) than fetuin-A and adiponectin, with their AUC values of 0.755, 0.709 and 0.708, respectively. F/A ratio is a more sensitive index for evaluating MS than either fetuin-A or adiponectin in the elderly.

中文翻译：

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Fetuin-a与脂联素之比是评估老年人代谢综合征的敏感指标

在最近的证据支持下，胎球蛋白A和脂联素之间存在着重要的关联，代谢综合征（MS）以高血糖，中枢性肥胖和胰岛素抵抗为主要成分，但它们的生物学功能却相反。这项研究的目的是验证是否胎球蛋白A /脂联素比（F / A比）是比胎球蛋白A或脂联素更敏感的MS评价指标。在这项横断面研究中，从体格检查数据库中选择了465位老年受试者。使用酶联免疫吸附测定（ELISA）方法测量血清中胎球蛋白A和脂联素的水平。采用Spearman秩相关系数，线性回归和logistic回归分析来估计胎球蛋白A，脂联素和F / A比值与MS及其成分的相关性，进行接收机工作特性曲线分析，以评价上述指标的预测值。与胎球蛋白A或脂联素相比，F / A比值与MS的所有成分均显着相关，即使在调整了潜在的混杂因素后，这种相关性仍很显着（P <0.05）。Logistic回归分析表明，F / A比值与事件MS（校正后的OR：1.466； 95％CI：1.189-1.808）相比于胎球蛋白A（校正后的OR：1100； 95％CI：1.020-1.186）和脂联素之间的相关性更强。 （调整后的OR：0.760； 95％CI：0.664-0.871）。ROC分析显示，F / A比曲线下面积（AUC）大于胎球蛋白A和脂联素，其AUC值分别为0.755、0.709和0.708。