Vitamin E, which is critically important in the whole process of reproduction, can antagonize the oxidative stress caused by the oxygen free radicals and antioxidant imbalance and regulate normal physiological function of the reproductive system. The effect of short-term supplementation of vitamin E on outcomes of infertile women with polycystic ovary syndrome (PCOS) when they underwent ovulation induction with clomiphene citrate (CC) and human menopausal gonadotropin (HMG) remains unknown. This was a retrospective cohort clinical trial from October 2015 to April 2017. A total of 321 PCOS cases underwent ovulation induction with CC and HMG. Patients in group A (n = 110) did not receive vitamin E while patients in group B (n = 105) and group C (n = 106) received oral treatment of vitamin E at 100 mg/day during follicular phase and luteal phase, respectively. It was observed no significant differences of ovulation rate, clinical pregnancy rate, and ongoing pregnancy rate among the three groups. It was interesting that dosage of HMG were significant lower in group B compared with those in group A and group C (P<0.05). A short-term supplementation of vitamin E can improve oxidative stress, and reduce exogenous HMG dosage to lower the economic cost with a similar pregnancy rate in the ovulation induction cycle. However, the supplementation does not alter the pregnancy rate in the ovulation induction cycle. ChiCTR-OOC-14005389, 2014.

中文翻译：

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短期维生素E补充对不育PCOS妇女排卵诱导下氧化应激的影响：一项回顾性队列研究。

维生素E在整个繁殖过程中至关重要，它可以拮抗由氧自由基和抗氧化剂失衡引起的氧化应激，并调节生殖系统的正常生理功能。短期补充维生素E对多囊卵巢综合症（PCOS）的不育女性进行柠檬酸克罗米芬（CC）和人类更年期促性腺激素（HMG）诱导排卵时的效果尚不清楚。这是一项回顾性队列临床试验，从2015年10月至2017年4月。总共321例PCOS病例接受CC和HMG诱导排卵。A组（n = 110）的患者未接受维生素E，而B组（n = 105）和C组（n = 106）的患者在卵泡期和黄体期接受100 mg /天的维生素E口服治疗，分别。观察到三组之间的排卵率，临床妊娠率和持续妊娠率无显着差异。有趣的是，与A组和C组相比，B组的HMG剂量显着降低（P <0.05）。短期补充维生素E可以改善氧化应激，减少外源HMG剂量，从而在排卵诱导周期中以相似的怀孕率降低经济成本。但是，补充剂不会改变排卵诱导周期中的怀孕率。ChiCTR-OOC-14005389，2014年。有趣的是，与A组和C组相比，B组的HMG剂量显着降低（P <0.05）。短期补充维生素E可以改善氧化应激，减少外源HMG剂量，从而在排卵诱导周期中以相似的怀孕率降低经济成本。但是，补充剂不会改变排卵诱导周期中的怀孕率。ChiCTR-OOC-14005389，2014年。有趣的是，与A组和C组相比，B组的HMG剂量显着降低（P <0.05）。短期补充维生素E可以改善氧化应激，减少外源HMG剂量，从而在排卵诱导周期中以相似的怀孕率降低经济成本。但是，补充剂不会改变排卵诱导周期中的怀孕率。ChiCTR-OOC-14005389，2014年。