Postoperative sore throat (POST) is a common, undesirable result of endotracheal intubation during general anaesthesia. This study aimed to evaluate the effectiveness of benzydamine hydrochloride (BH) spray in reducing the incidence of POST in paediatric patients. This randomized, double-blind, prospective study included 142 children 6–12 years of age, who were randomly assigned to receive either BH spray or control. After induction of anaesthesia, direct laryngoscope was placed and BH spray was applied to the upper trachea and vocal cord in the BH group and intubation was performed using a cuffed tube lubricated with normal saline. Intubation in the control group was performed using a cuffed tube lubricated with normal saline without any intervention. The balloon was inflated to a pressure of 20 cmH2O. Patients were extubated after fully awakened and transferred to the post-anaesthetic care unit (PACU), where they were examined for the presence of POST and any adverse events 30 min after arrival to the PACU. Postoperative pain was evaluated using a smartphone application. Seventy-one patients were allocated to each group. The incidence of POST in the BH group did not differ from that in the control group (control: BH = 35 (49.3%): 42 (59.2%); P = 0.238); postoperative pain was also similar between the groups. Other complications, such as breath holding, secretions, coughing, laryngospasm and desaturation events, did not differ between the groups. Application of prophylactic BH spray to the vocal cords and upper trachea was not proven to reduce POST in paediatric patients. NCT03074968 (ClinicalTrials.gov, Feb 26, 2017).

中文翻译：

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盐酸苯乙胺对儿童拔管后喉咙痛的影响：一项随机对照试验。

术后喉咙痛（POST）是全身麻醉期间气管插管的常见不良结果。这项研究旨在评估盐酸苯乙胺（BH）喷雾剂在降低儿科患者POST发病率方面的有效性。这项随机，双盲，前瞻性研究纳入了142名6至12岁的儿童，他们被随机分配接受BH喷雾剂或对照。麻醉诱导后，将直接喉镜放置在BH组的上气管和声带上应用BH喷雾，并使用用生理盐水润滑的袖管进行插管。对照组的插管是使用装有生理盐水的袖带管进行的，无需任何干预。将气球充气至20cmH 2 O的压力。患者完全苏醒后拔管，然后转移到麻醉后护理病房（PACU），在那里检查他们是否存在POST以及到达PACU后30分钟的任何不良事件。使用智能手机应用程序评估术后疼痛。每组分配71名患者。BH组的POST发生率与对照组无差异（对照组：BH = 35（49.3％）：42（59.2％）； P = 0.238）；两组之间的术后疼痛也相似。两组之间的其他并发症，如屏气，分泌物，咳嗽，喉痉挛和去饱和事件，没有差异。尚未证明将预防性BH喷雾剂应用于声带和上气管可降低小儿患者的POST。NCT03074968（ClinicalTrials.gov，2017年2月26日）。