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The combination of a male donor's high muscle mass and quality is an independent protective factor for graft loss after living donor liver transplantation
American Journal of Transplantation ( IF 8.8 ) Pub Date : 2020-04-03 , DOI: 10.1111/ajt.15884 Yosuke Miyachi 1 , Toshimi Kaido 1 , Masaaki Hirata 1 , Sena Iwamura 1 , Siyuan Yao 1 , Hisaya Shirai 1 , Naoko Kamo 1 , Ryuji Uozumi 2 , Shintaro Yagi 1 , Shinji Uemoto 1
American Journal of Transplantation ( IF 8.8 ) Pub Date : 2020-04-03 , DOI: 10.1111/ajt.15884 Yosuke Miyachi 1 , Toshimi Kaido 1 , Masaaki Hirata 1 , Sena Iwamura 1 , Siyuan Yao 1 , Hisaya Shirai 1 , Naoko Kamo 1 , Ryuji Uozumi 2 , Shintaro Yagi 1 , Shinji Uemoto 1
Affiliation
We evaluated the hypothesis that grafts from donors with high muscle mass and quality may have a better outcome after living‐donor‐liver‐transplantation (LDLT) than those from usual donors. A total of 376 primary adult‐to‐adult LDLT cases were enrolled in this study. Donor skeletal muscle mass index (SMI) and intramuscular adipose tissue content (IMAC) were used as markers of muscle mass and quality. In male donor cases (n = 198), those with higher SMI and lower IMAC than age‐adjusted values were defined as the “high muscularity donors” (n = 38) and the others were defined as the “control” (n = 160). The high muscularity donor showed better 1‐year (97% vs 82%, P = .020) and overall graft survival rate (88% vs 67%, P = .024) than the control group after LDLT. Contrastingly, the influence of the muscularity was not observed in female donor cases. Multivariable analysis including donor age confirmed that a high muscularity donor was an independent protective factor for overall graft survival after LDLT (hazard ratio, 0.337; 95% CI: 0.101‐0.838; P = .017). Our study first confirmed that high muscle mass and quality of a male donor is a protective factor of allograft loss after LDLT, independently from donor age.
中文翻译:
男性供体的高肌肉量和质量是活体肝移植后移植物丢失的独立保护因素
我们评估了这样一个假设,即来自肌肉质量和质量高的供体的移植物在活体供肝移植 (LDLT) 后可能比来自普通供体的移植物具有更好的结果。本研究共纳入 376 例原发性成人至成人 LDLT 病例。供体骨骼肌质量指数 (SMI) 和肌内脂肪组织含量 (IMAC) 被用作肌肉质量和质量的标志。在男性供体病例 (n = 198) 中,SMI 较高且 IMAC 低于年龄调整值的那些被定义为“高肌肉供体”(n = 38),其他被定义为“对照”(n = 160 ). 高肌肉供体显示出更好的 1 年(97% 对 82%,P = .020)和总体移植物存活率(88% 对 67%,P = .024) 优于 LDLT 后的对照组。相比之下,在女性供体病例中未观察到肌肉发达的影响。包括供体年龄在内的多变量分析证实,高肌肉供体是 LDLT 后整体移植物存活的独立保护因素(风险比,0.337;95% CI:0.101-0.838;P = .017)。我们的研究首先证实,男性供体的高肌肉质量和质量是 LDLT 后同种异体移植物丢失的保护因素,与供体年龄无关。
更新日期:2020-04-03
中文翻译:
男性供体的高肌肉量和质量是活体肝移植后移植物丢失的独立保护因素
我们评估了这样一个假设,即来自肌肉质量和质量高的供体的移植物在活体供肝移植 (LDLT) 后可能比来自普通供体的移植物具有更好的结果。本研究共纳入 376 例原发性成人至成人 LDLT 病例。供体骨骼肌质量指数 (SMI) 和肌内脂肪组织含量 (IMAC) 被用作肌肉质量和质量的标志。在男性供体病例 (n = 198) 中,SMI 较高且 IMAC 低于年龄调整值的那些被定义为“高肌肉供体”(n = 38),其他被定义为“对照”(n = 160 ). 高肌肉供体显示出更好的 1 年(97% 对 82%,P = .020)和总体移植物存活率(88% 对 67%,P = .024) 优于 LDLT 后的对照组。相比之下,在女性供体病例中未观察到肌肉发达的影响。包括供体年龄在内的多变量分析证实,高肌肉供体是 LDLT 后整体移植物存活的独立保护因素(风险比,0.337;95% CI:0.101-0.838;P = .017)。我们的研究首先证实,男性供体的高肌肉质量和质量是 LDLT 后同种异体移植物丢失的保护因素,与供体年龄无关。