Burn wound healing remains a challenging health problem worldwide due to the lack of efficient and precise therapy. Inherent oxidative stress following burn injury is importantly responsible for prolonged inflammation, fibrotic scar, and multiple organ failure. Herein, a bioinspired antioxidative defense system coupling with in situ forming hydrogel, namely, multiresponsive injectable catechol‐Fe³⁺ coordination hydrogel (MICH) matrix, is engineered to promote burn‐wound dermal repair by inhibiting tissue oxidative stress. This MICH matrix serves as the special traits of “Fe‐superoxide dismutases,” small molecular antioxidant (vitamin E), and extracellular matrix (ECM) in alleviating cellular oxidative damage, which demonstrates precise scavenging on reactive oxygen species (ROS) of different cellular locations, blocking lipid peroxidation and cell apoptosis. In in vivo burn‐wound treatment, this MICH promptly integrates with injured surrounding tissue to provide hydration microenvironment and physicochemical ECM for burn wounds. Importantly, the MICH matrix suppresses tissue ROS production, reducing the inflammatory response, prompting re‐epithelization and neoangiogenesis during wound healing. Meanwhile, the remodeling skin treated with MICH matrix demonstrates low collagen deposition and normal dermal collagen architecture. Overall, the MICH prevents burn wound progression and enhances skin regeneration, which might be a promising biomaterial for burn‐wound care and other disease therapy induced by oxidative stress.

中文翻译：

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具有精确氧化应激防御功能的可注射酶基水凝胶基质，可促进烧伤皮肤的修复。

由于缺乏有效和精确的治疗方法，烧伤伤口愈合仍然是世界范围内具有挑战性的健康问题。烧伤后固有的氧化应激对长时间的炎症，纤维化瘢痕和多器官衰竭至关重要。在这里，生物启发的抗氧化防御系统与原位形成的水凝胶结合，即多响应注射儿茶酚-Fe ³⁺配位水凝胶（MICH）基质旨在通过抑制组织氧化应激来促进烧伤皮肤修复。该MICH基质具有“铁超氧化物歧化酶”，小分子抗氧化剂（维生素E）和细胞外基质（ECM）的特殊特性，可减轻细胞的氧化损伤，这表明可以精确清除不同细胞的活性氧（ROS）位置，阻止脂质过氧化和细胞凋亡。在体内烧伤治疗中，此MICH可迅速与受伤的周围组织融合，为烧伤创面提供水化微环境和理化ECM。重要的是，MICH基质可抑制组织ROS的产生，减少炎症反应，并在伤口愈合过程中促进上皮再生和新生血管生成。与此同时，经MICH基质处理的重塑皮肤表现出较低的胶原蛋白沉积和正常的真皮胶原蛋白结构。总体而言，MICH可防止烧伤创面进展并增强皮肤再生，这可能是一种有前途的生物材料，可用于烧伤护理和其他由氧化应激引起的疾病治疗。