The true producer of the clinically relevant microtubule‐destabilizing agent dolastatin 15 has been determined. Isogenic cell‐line screening indicated that its cytotoxicity is mediated by HIF‐1α, controlling angiogenesis. Dolastatin 15 inhibited vascularization in cell and zebrafish models, thus suggesting its potential to treat vascularized tumors. RNA‐seq provided a global snapshot of the anticancer effects.

中文翻译：

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来自海洋蓝藻的 Dolastatin 15 抑制 HIF-1α 介导的癌细胞活力和血管化。

已确定临床相关微管不稳定剂多拉司他汀 15的真正生产者。等基因细胞系筛选表明其细胞毒性由 HIF-1α 介导，控制血管生成。Dolastatin 15 抑制细胞和斑马鱼模型中的血管化，从而表明其治疗血管化肿瘤的潜力。RNA-seq 提供了抗癌作用的全局快照。