The objective of this study is to review the ocular surface changes and complications of patients with Sjögren syndrome and assess their visual impact. A retrospective, cross-sectional, observational, and descriptive study of patients with Sjögren syndrome diagnosed according to the American–European Consensus Group criteria was designed. Data including age, gender, the reason for consultation, associated systemic disease, visual acuity, and ocular complications were recorded. Dry eye tests including tear meniscus thickness; tear film break-up time; ocular surface staining (fluorescein and lissamine green); and Schirmer I test were performed. A total of 249 patients, 233 women (93.6%) and 16 men (6.4%) were studied. Meibomian gland dysfunction was found in 46% (n = 229 eyes) patients; shortened tear film break-up time in 44% (n = 220 eyes); decreased tear meniscus in 49% (n = 243 eyes); significant superficial punctate keratopathy in 49% (n = 242 eyes); a mean ocular surface staining score of 5.92 points; and a low score for Schirmer I test (mean = 5.4 mm). Eyes with a 4 + corneal fluorescein score showed the worst BCVA (mean = 0.63 ± 0.66 LogMAR, ≤ 20/80 Snellen eq., 95% CI 0.29–0.97), compared to 1 + to 3 + scores (mean = 0.211 ± 0.37 LogMAR, 20/32 Snellen eq., 95% CI 0.53–1.15). Ten eyes (4.0%) presented central corneal ulceration with a mean visual acuity of 20/500 (96% visual loss). Ocular surface alterations related to severe dry eye and complications from Sjögren syndrome may have a significant impact on visual acuity. Secondary Sjögren syndrome to rheumatoid arthritis had the worse dry eye prognosis, visual outcome, and ocular complications.

这项研究的目的是审查干燥综合征患者的眼表变化和并发症，并评估其视觉影响。设计了一项根据美国-欧洲共识小组标准诊断出的干燥综合征患者的回顾性，横断面，观察性和描述性研究。记录包括年龄，性别，会诊原因，相关系统疾病，视力和眼部并发症在内的数据。干眼测试，包括泪液半月板厚度；泪膜破裂时间；眼表染色（荧光素和赖氨绿）；进行了Schirmer I测试。共研究了249例患者，其中233例女性（93.6％）和16例男性（6.4％）。发现46％的睑板腺功能异常（n = 229眼）患者；泪膜破裂时间缩短了44％（n  = 220眼）；泪液半月板减少了49％（n  = 243眼）；显着的点状点状角膜病49％（n = 242眼）；平均眼表染色评分为5.92分；Schirmer I测试得分较低（平均= 5.4毫米）。角膜荧光素得分为4 +的眼睛显示出最差的BCVA（平均值= 0.63±0.66 LogMAR，≤20/80 Snellen eq。，95％CI 0.29–0.97），而得分为1 +至3 +得分（平均值= 0.211±0.37） LogMAR，20/32 Snellen等效，95％CI 0.53-1.15）。十只眼（4.0％）表现为角膜中央溃疡，平均视力为20/500（视力丧失96％）。与严重干眼症和干燥综合征有关的眼表改变可能对视力有重大影响。类风湿关节炎继发性干燥综合征的干眼预后，视觉结果和眼部并发症均较差。