Untreated hyperthyroidism may develop serious complications. This attempt was made to investigate the potential of Aloe vera gel in regulating experimentally induced hyperthyroidism in rats. Female Wistar rats were made hyperthyroid with L-thyroxine (L-T4) at 0.5 mg/kg/day, i.p. for 14 days and the effects of Aloe vera methanolic fraction (AVMF) (50 or 500 mg/kg/day, p.o.,) and a conventional antithyroid drug propylthiouracil (PTU) (10 mg/kg, i.p.) for 30 days were studied in those hyperthyroid rats. At the end, alterations in serum thyroid hormones and thyroid stimulating hormone (TSH); hepatic 5'mono-deiodinase-1(5'D1) activity, oxidative stress markers and antioxidants; serum inflammatory cytokines and the expression of thyrotropin receptor in thyroid gland were evaluated in all experimental animals. Hyperthyroid condition was confirmed by an increase in thyroid hormone levels and hepatic 5'D-1 activity with a decrease in TSH. However, either AVMF or PTU treatment in hyperthyroid rats decreased the levels of thyroid hormones and 5'D1 activity. AVMF administration in T4-induced rats also decreased the oxidative stress markers such as thiobarbituric acid reactive substances and lipid hydroperoxides and increased the antioxidant levels in liver tissues. Levels of liver marker enzymes, cytokines and different lipids were decreased in T4-induced AVMF treated rats. Further, a down regulation in the TSHR expression in thyroid was observed in AVMF or PTU treated groups. All these thyroid inhibiting effects were supported by an improvement in thyroid histology in hyperthyroid rats. It appears, about 15 compounds, as evidenced by LC-MS/MS study, mostly phenolics are involved in this anti-thyroid effects of the test compound.

中文翻译：

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芦荟凝胶通过抑制促甲状腺激素受体，炎症和氧化应激，对L-T4诱导的甲状腺功能亢进有改善作用。

未经治疗的甲状腺功能亢进症可能会导致严重的并发症。进行此尝试以研究芦荟凝胶调节大鼠实验性甲状腺功能亢进症的潜力。雌性Wistar大鼠以0.5 mg / kg /天的L-甲状腺素（L-T4）腹腔注射14天，服用芦荟甲醇馏分（AVMF）（50或500 mg / kg / day，口服）和传统的抗甲状腺药物丙硫氧嘧啶（PTU）（10 mg / kg，腹腔注射），用于这些甲状腺功能亢进的大鼠，历时30天。最后，血清甲状腺激素和甲状腺刺激激素（TSH）的改变；肝脏5'mono-deiodinase-1（5'D1）活性，氧化应激标记物和抗氧化剂；在所有实验动物中评估血清炎性细胞因子和甲状腺中促甲状腺激素受体的表达。甲状腺激素水平升高和肝脏5'D-1活性升高，TSH降低证实甲状腺功能亢进。但是，对甲亢大鼠进行AVMF或PTU治疗都会降低甲状腺激素水平和5'D1活性。在T4诱导的大鼠中施用AVMF还可以降低氧化应激标志物，例如硫代巴比妥酸反应性物质和脂质氢过氧化物，并增加肝组织中的抗氧化剂水平。在T4诱导的AVMF处理的大鼠中，肝标志物酶，细胞因子和不同脂质的水平降低。此外，在AVMF或PTU治疗组中观察到甲状腺TSHR表达下调。所有这些甲状腺抑制作用都得到甲状腺功能亢进大鼠甲状腺组织学改善的支持。LC-MS / MS研究表明，大约有15种化合物，