A new cyclometalated Au(III) complex highlighting a naphthoquinone-C^N scaffold with formula (NQ-N^C)Au^III(SAd)Cl, 1, in which NQ-N^C: 2-(5-amino-benzo[h]quinolone)-3-(3-methyl-2-butenyl)-1,4-naphthoquinone, HSAd: 1-adamantanethiol, was synthesized and characterized. The interaction of complex 1 with cysteine (CysH) was experimentally and theoretically studied. Complex 1 was more active against MCF-7 and A549 cancer cell lines and less active in a healthy cell (non-tumorigenic cells, MRC-5) than cisplatin. The DNA binding and inhibition of thioredoxin reductase of complex 1 were studied and compared with the molecular docking results. The generation of reactive oxygen species (ROS) and apoptosis of this new complex were also investigated.

Graphic abstract

中文翻译：

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靶向硫氧还蛋白还原酶的新型环金属化金（III）络合物：作为细胞毒性剂和机制的探索。

一种新的环金属化的Au（III）配合物，突出了具有式（NQ-N ^ C）Au ^III（SAd）Cl，1的萘醌-C ^ N支架，其中NQ-N ^ C：2-（5-氨基-苯并合成并表征了[h]喹诺酮）-3-（3-甲基-2-丁烯基）-1,4-萘醌，HSAd：1-金刚烷硫醇。对复合物1与半胱氨酸（CysH）的相互作用进行了实验和理论研究。与顺铂相比，复合物1对MCF-7和A549癌细胞的活性更高，而在健康细胞（非致瘤细胞，MRC-5）中的活性更低。配合物1的DNA结合和硫氧还蛋白还原酶的抑制进行了研究并与分子对接结果进行了比较。还研究了这种新复合物的活性氧（ROS）的产生和细胞凋亡。

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