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Iodine-Catalyzed [3+2]-Cyclization of Substituted Benzylidenemalononitriles and Ethyl Glycinate Hydrochloride: Direct Access to 5-Amino-1H-pyrrole-2-carboxylates
Synlett ( IF 2 ) Pub Date : 2020-04-02 , DOI: 10.1055/s-0040-1707466
Cunde Wang 1 , Zhenjie Su 1 , Shan Wang 1 , Naili Luo 1
Affiliation  

An iodine-catalyzed [3+2]-cycloaddition reaction of substituted benzylidenemalononitriles and ethyl glycinate hydrochloride in DMF has been developed for the synthesis of 5-amino-1H-pyrrole-2-carboxylates. This efficient method provides access to a variety of structurally diverse pyrrole-2-carboxylate derivatives. The structure of a typical product was confirmed by X-ray crystallography.

中文翻译:

碘催化的 [3+2]-环化取代亚苄基丙二腈和甘氨酸乙酯盐酸盐:直接获得 5-Amino-1H-pyrrole-2-carboxylates

已开发出碘催化的 [3+2]-取代亚苄基丙二腈和甘氨酸乙酯盐酸盐在 DMF 中的 [3+2]-环加成反应,用于合成 5-氨基-1H-吡咯-2-羧酸盐。这种有效的方法提供了获得各种结构不同的 pyrrole-2-carboxylate 衍生物的途径。典型产物的结构由 X 射线晶体学证实。
更新日期:2020-04-02
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