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CtIP promotes the motor activity of DNA2 to accelerate long-range DNA end resection [Biochemistry]
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2020-04-02 Ilaria Ceppi, Sean M. Howard, Kristina Kasaciunaite, Cosimo Pinto, Roopesh Anand, Ralf Seidel, Petr Cejka
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2020-04-02 Ilaria Ceppi, Sean M. Howard, Kristina Kasaciunaite, Cosimo Pinto, Roopesh Anand, Ralf Seidel, Petr Cejka
To repair a DNA double-strand break by homologous recombination, 5′-terminated DNA strands must first be resected to reveal 3′-overhangs. This process is initiated by a short-range resection catalyzed by MRE11-RAD50-NBS1 (MRN) stimulated by CtIP, which is followed by a long-range step involving EXO1 or DNA2 nuclease. DNA2 is a bifunctional...
中文翻译：
CtIP促进DNA2的运动活性，以加速远距离DNA末端切除[生物化学]
为了通过同源重组修复DNA双链断裂，必须首先切除5'末端的DNA链以显示3'突出端。此过程由CtIP刺激的MRE11-RAD50-NBS1（MRN）催化的短距离切除启动，随后是涉及EXO1或DNA2核酸酶的长距离步骤。DNA2是一种双功能...
更新日期：2020-04-03
中文翻译：
CtIP促进DNA2的运动活性，以加速远距离DNA末端切除[生物化学]
为了通过同源重组修复DNA双链断裂，必须首先切除5'末端的DNA链以显示3'突出端。此过程由CtIP刺激的MRE11-RAD50-NBS1（MRN）催化的短距离切除启动，随后是涉及EXO1或DNA2核酸酶的长距离步骤。DNA2是一种双功能...
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